MASSACHUSETTS - Key Persons
Job Titles:
- Professor of Medicine at the University of Colorado School of Medicine
Charles A. Dinarello, M.D. is Professor of Medicine at the University of Colorado School of Medicine in Denver. Dr. Dinarello, a member of the National Academy of Sciences, is internationally renowned for his studies of the pathobiology of cytokines in a wide variety of disease states and is credited with the characterization of IL-1, an important cytokine involved in immunity and inflammation. Dr. Dinarello is particularly interested in studying pro-inflammatory cytokines and cytokine intracellular pathways involved in the regulation of inflammation and host responses to infection and trauma. As the world's fourth most cited scientist during the past 20 years (1983-2002), Dr. Dinarello contributes to our program goals to better understand and characterize the altered immune response following major trauma.
Douglas T. Golenbock, M.D. is Professor of Medicine and Chief of the Division of Infectious Diseases and Immunology at the University of Massachusetts Medical School. Dr. Golenbock conducts important research in characterizing the cellular receptors used by certain leukocytes in response to acute and chronic infection. His laboratory has made significant contributions to understanding the pathophysiology of sepsis and pelvic inflammatory disease through the study of cellular activation by bacterial products. Dr. Golenbock's research in studying the actions of bacterial lipopolysaccharide (LPS) is directly related to our research program studies in LPS-challenged human volunteers.
G. Tom Shires, M.D. is self-described as "semi-retired" since 1991, yet remains Director of the Nevada Trauma Institute for research and teaching, a non-clinical institute that supports the Level I Trauma Center at the University of Nevada School of Medicine. The Institute is supported by research grants in injury from various trauma foundations and injury prevention programs as well as the Centers for Disease Control. A former dean of the Cornell University School of Medicine, Dr. Shires is a Professor of Surgery at the University of Nevada, and he has the distinction of being the last clinician on the NIGMS Council until recently. He has had a very long history with NIGMS and is quite knowledgeable about the mission and scope of NIGMS.
Elizabeth A. Winzeler, Ph.D. is an Associate Professor of Cell Biology at The Scripps Research Institute, with areas of expertise including genetics, genomics, and bioinformatics. Dr. Winzeler is particularly interested in the application of high-throughout genomic technologies in organisms such as yeast and diseases like malaria. She has extensive experience in developing relational databases that include phenotypic and genomic information. She also has an appointment in the Novartis Institute to examine genomic expression patterns in cancer; many of her activities in the Novartis Institute are highly related to our goals in the Glue Grant. Dr. Winzeler plays an important role in providing guidance in the development of our genomic database. Dr. Winzeler serves as the current chairperson of our Advisory Committee.
Job Titles:
- Professor and Director of the Center for Injury Research and Policy Johns Hopkins Bloomberg School of Public
Ellen J. MacKenzie, Ph.D. is Professor and Director of the Center for Injury Research and Policy Johns Hopkins Bloomberg School of Public Health. As Director, Dr. MacKenzie oversees center research that involves a spectrum of injury related issues from prevention to long-term outcomes. Of particular interest to Dr. MacKenzie is the impact of health services and healthy policy on the consequences of traumatic injury. She currently chairs the advisory committee of the Centers for Disease Control - National Center for Injury Prevention and Control (NCIPC). Dr. MacKenzie offers her expertise as a leader in the development and evaluation of tools for measuring injury severity and outcome.
Eric P. Hoffman, Ph.D. is the Director of the Research Center for Genetic Medicine and Professor of Molecular Medicine at Children's National Medical Center, George Washington University. The Center is rapidly expanding efforts to better understand the molecular basis of human disease and applications of molecular diagnostics and experimental therapeutics. Dr. Hoffman has a long-term interest in genetics and its implications for health and disease. He offers his expertise and leadership in applications of microarrays (gene expression profiling) to study disease and develop diagnostic and therapeutic modalities.
Job Titles:
- President and Chief Executive Officer of Geisinger Health System in Pennsylvania
Glenn D. Steele, Jr., M.D., Ph.D. is the President and Chief Executive Officer of Geisinger Health System in Pennsylvania. Dr. Steele is also a former medical school dean at the Pritzker School of Medicine as well as the dean of the Biological Sciences Division and Vice President of Medical Affairs at the University of Chicago. His clinical background is in oncology and Dr. Steele offers his expertise and leadership in the organization and operation of multi-center clinical trials, which is an invaluable asset in our human studies programs. He has been a leader for many years of the multi-center trials program at the American College of Surgeons.
Job Titles:
- Professor, Department of Pathology at University of Michigan Medical School
Peter A. Ward, M.D. is Godfrey D. Stobbe Professor, Department of Pathology at University of Michigan Medical School. Dr. Ward's research interests involve molecular mechanisms of the inflammatory response. His research activities relate to mediators and regulators of the inflammatory response, with a particular emphasis on cytokines, complement and protease inhibitors. He is an elected member of the U.S. National Academy of Sciences Institute of Medicine, the American Association for the Advancement of Science and the National Academies of Science.
John F. Burke, M.D. is the Helen Andrus Benedict Professor of Surgery Emeritus at Harvard Medical School and Chief of the Trauma Service Emeritus at Massachusetts General Hospital. During his tenure as MGH Burn Center director and Chief of Staff at Boston's Shriners Hospital, Dr. Burke is perhaps best known for pioneering the concept of early burn excision, which demonstrated a decrease in hospital length of stay and mortality for massively burned patients. Dr. Burke and MIT chemistry professor Ioannis V. Yannas developed the first artificial (synthetic) skin used to treat burn victims, announced in 1981. Through "the innovative research of Dr. John Burke and the heroic work of the Burn Center at Mass General Hospital", Sumner M. Redstone in 2007 pledged $35 million to the MGH Burn Center.
K. Frank Austen, M.D. is the Astrazeneca Professor of Respiratory and Inflammatory Diseases in the Department of Medicine, Harvard Medical School and Brigham and Women's Hospital. Dr. Austen served as Chairman of the Department of Medicine at the Robert B. Brigham Hospital and was an integral figure in the historic merger that created the hospital we know today as Brigham and Women's. Within the field of eicosanoid research, he is perhaps best known for his discoveries related to inflammatory mediators, including the cysteinyl leukotrienes. His research concerning the role of leukotrienes, formerly known as SRS-A, in asthma and pulmonary disease opened new avenues for therapy.
Job Titles:
- Professor of Internal Medicine
Robert S. Munford, M.S., M.D. is Professor of Internal Medicine and Microbiology at UT Southwestern Medical Center. An infectious disease specialist, Dr. Munford's research career has focused on host mechanisms for detoxifying bacterial LPS. He pioneered in the use of inflammation-regulated promoter-enhancer systems to control the production of anti-inflammatory recombinant proteins in vivo ("physiologically-responsive gene therapy"). Prior to joining the faculty of UT Southwestern, Dr. Munford was an epidemiologist with the Centers for Disease Control and Prevention.
Job Titles:
- Chief of the Burn Service
- Professor of Surgery
Job Titles:
- Chief of the Burn Service
- Professor of Surgery