MOTIF

High-throughput DNA binding analysis of HNF4a, RXRa and COUPTF2 reveals an HNF4-specific motif... Nuclear Receptor Binding Site Scanner (NRBS Scanner) is a web-based tool designed to identify potential nuclear receptor binding sites in any DNA sequence. There are two applications... The first application searches for binding sites for a given nuclear receptor using support vector machine (SVM) prediction. Binding sites are inferred by an SVM model trained on >1000 unique sequences that have been experimentally validated using Protein Binding Microarrays (PBMs). The sites with a probability of binding greater than 0.5 (maximum is 1.0) and their start positions in the user-provided DNA are shown.

Primary location: Riverside United States