In a normal muscle cell, the GAA enzyme breaks down glycogen, a type of sugar, so the cell can use it for energy when needed. To get to the muscle cell, GAA needs the help of M6P, a part of a molecule...
NEXVIAZYME is an M6P-enriched ERT for LOPD and is scientifically designed to be absorbed effectively by muscle cells...
Patients treated with NEXVIAZYME have experienced severe IARs. If severe IARs occur, consider immediate discontinuation of NEXVIAZYME, initiation of appropriate medical treatment, and the benefits and risks of readministering NEXVIAZYME following severe IARs. Patients with an acute underlying illness at the time of NEXVIAZYME infusion may be at greater risk for IARs. Patients with advanced Pompe disease may have compromised cardiac and respiratory function, which may predispose them to a higher risk of severe complications from IARs.