JOHN LABORATORY

We demonstrated that vitamin B3 (nicotinamide) potently prevents glaucoma in a mouse model. We have a strong interest in the role of altered metabolism in various neurodegenerations with mnjoarfocus on IOP elevation and retinal disease. We are involved with clinical trials and other studies to further evaluate the efficacy of vitamin B3 and the role of metabolism in human glaucoma, with inital positive findings... Training is also an important component of our program. with trainees obtaining hands on experience while conducting research projects. Our approach is multidisciplinary with projects involving diverse expertise including clinical evaluation, genetics, genomics/gene expression (single cell sequencing, spatial transcriptomics, etc.), gene therapy, molecular biology, pathology, physiology, neurobiology, microscopy, imaging and metabolomics/metabolism. We are generating large complex datasets that require data science/biostatistics and innovative computational analyses. This..