JEROEN PASTERKAMP

Research in the Pasterkamp lab focuses on understanding 1) the signaling events and molecular mechanisms involved in the development of neuronal connections, and 2) the molecular mechanisms underlying changes in or loss of neuronal connectivity during neurological disease (in particular motor neuron disorders such as amyotrophic lateral sclerosis (ALS) and epilepsy). This research concentrates on mouse models and humanized cell models (iPSC, organoids) using an integrated approach involving molecular cell biology, neuroanatomy, (in vivo) functional proteomics, microscopy, genome editing, and mouse genetics.