POLARIS GROUP

Polaris Group is a multinational biotechnology company focused on developing novel anti-cancer therapies... Polaris Group is involved in every stage of the drug development process. Our family of companies harnesses structure-based drug design technology to create novel oncology therapies, conducts clinical studies at top-tier cancer centers worldwide and operates CGMP production facilities in Northern California and China... Pegargiminase is a novel therapeutic protein being developed for cancers with a unique metabolic trait: their cells are unable to create arginine, an amino acid that is essential for cancer cell proliferation and survival. Because the cells can't create arginine on their own, they must rely on arginine in the patient's plasma. But Pegargiminase deprives the cancer cells of this amino acid by converting plasma-borne arginine into citrulline. While healthy cells are able to easily convert citrulline back into arginine through a process known as the urea cycle,..

Primary location: San Diego United States