RNA BIOLOGY

Computational analysis of genomic information carried out at the nodal laboratory, IGIB, gave early leads on miRNA mediated regulation in a number of key areas pertaining to molecular medicine. This project aims to explore the functional relevance of these early leads using experimental approaches towards understanding the regulatory potential of these small regulatory RNA molecules. Besides this focus on human disease, the project is also expected to improve our understanding of these new players in gene regulation... The project is set up to tap into the expertise of several groups at IGIB with core expertise in human genetics, disease related phenomena like apoptosis and the functional genomics of zebrafish. Furthermore, the project will bring together the expertise of members from other CSIR labs: IICT will adapt their experience in targeted delivery of DNA for ncRNA delivery; IICB will explore small RNA-ligand interaction to develop novel molecules to target RNA and NCL will..

Primary location: Tokyo Japan