HOELZ LABORATORY

Figure 1. The PAS domain region of PER. The 1224-residue PER protein contains two PAS domains (PAS-AB) adjacent to one another in the N-terminal half of the protein. A classic PER allele, PER long (perL), is caused by the point mutation V243D in PAS-A. Following the PER PAS domain region is another classic allele, PER short (per s), caused by the mutation S589N in the short mutable region (residues 585-600) where phosphorylation events lead to degradation. Interactions between PER and the clock proteins DBT, TIM, and cryptochrome (CRY) have been mapped to regions surrounding and overlapping the PER PAS domain region... Figure 2. The PER PAS domain structure. (a) Four PER PAS-AB dimers are found in the asymmetric unit (black/gray, red/magenta, blue/yellow, and orange/green). (b) Each molecule includes two PAS domain regions (PAS-A and PAS-B) followed by two additional helices. The final helix (αF) of one molecule wraps around the dimer to pack against the PAS-A β-sheet of the opposing..

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