MADRIGAL - Key Persons

Job Titles:

• Chief Financial Officer
• Member of the Leadership Team

Mr. Howarth brings more than 30 years of experience in healthcare finance, corporate development and operational roles. Prior to joining Madrigal, he held the role of Chief Operating Officer at Akcea Therapeutics and was Chief Financial Officer at Lycera Corp. He has also held roles as Chief Financial Officer and Chief Business Officer at moksha8, Chief Business Officer at Vitae Pharmaceuticals and Head of Venture Partnerships at GSK.

Job Titles:

• General Counsel
• Member of the Leadership Team

Brian J. Lynch has been at Madrigal since 2018. For 30 years before joining Madrigal, Mr. Lynch engaged in private practice and was a partner at the leading law firms headquartered in Washington, DC, Philadelphia and Silicon Valley (Hogan Lovells, Morgan Lewis and Cooley). His practice focused on value-enhancing M&A, equity and debt capital markets, and collaboration transactions and a broad range of representations for life sciences companies, including Madrigal. Mr. Lynch began his legal career at the Securities and Exchange Commission's Division of Corporation Finance in Washington, DC.

Job Titles:

• Director

David Milligan, Ph.D. has served on the Board of Directors since July 2016. He currently works as an independent consultant. Previously, Dr. Milligan was a partner at Bay City Capital, LLC, a life sciences investment firm, a position he held from 1997 through 2013. From 1979 to 1996, Dr. Milligan served as Senior Vice President and Chief Scientific Officer at Abbott Laboratories, a publicly-held life sciences company. Dr. Milligan currently serves as a director of Inspirotech and Xoult, both privately-held life sciences companies. During the past five years, Dr. Milligan has served as a director of Caliper Life Sciences, a publicly-held pharmaceutical and biotechnology company that was acquired by PerkinElmer Company, and served as a director of WebLOQ, Inc. a privately-held information technology security company. Dr. Milligan also served as Chairman and a director at Vicuron Pharmaceuticals, Inc., a public biopharmaceutical company acquired by Pfizer, from 1997 to 2005, as a director of Reliant Pharmaceuticals, Inc., a privately-held pharmaceutical company acquired by GlaxoSmithKline, from 1999 to 2007, as a director of Pathway Diagnostics Corporation, a privately-held diagnostics company acquired by Quest Diagnostics, Inc., from 2002 to 2008, as a director of ICOS Corporation, a publicly-held pharmaceutical company acquired by Eli Lilly, from 1995 to 2007 and as a director of Maxia Pharmaceuticals, Inc., a privately-held pharmaceutical company acquired by Incyte Corporation, from 1999 to 2003. Dr. Milligan received an A.B. in Chemistry from Princeton University and an M.S. and Ph.D. in Organic Chemistry from the University of Illinois.

Job Titles:

• Member of the Leadership Team
• Chief Data and Analytics Officer

Dr. Labriola has 35 years of experience in clinical development overseeing the global registration of 20 medicines. He spent more than 20 years at Bristol Myers Squibb as Head of Global Biometric Sciences where he was responsible for the team overseeing the company's NASH program among many other programs. Prior to joining Bristol Myers Squibb, he held positions of increasing responsibility at DuPont Pharmaceutical Company, managing biostatisticians and programmers for multiple therapeutic areas. Dr. Labriola began his career as a research biostatistician at Memorial Sloan Kettering Cancer Center and earned his Ph.D. in Mathematical Statistics from the University of Delaware.

Job Titles:

• Senior Vice President, Clinical and Technical Operations

Mr. Chiang has over 20 years of clinical trial experience starting his career at Bracco Diagnostics developing ultrasound contrast agents, followed by roles at Beacon Biosciences (now Icon Medical Imaging) and VIA Pharmaceuticals. Mr. Chiang joined Dr. Taub when she founded Madrigal and was directly involved in Madrigal's initial Phase 1 and 2 clinical trials.

Job Titles:

• Lead Director

Fred Craves, Ph.D. has served on the Board of Directors since July 2016. Previously, he served as Chairman of privately held Madrigal Pharmaceuticals from its inception to merger with Synta Pharmaceuticals Corp. Dr. Craves is a Managing Director and co-founder of Bay City Capital. In the course of his career, Dr. Craves has founded and managed several biotech companies. He previously served on the boards of several private and public companies. His current board memberships include Imidomics and Synchronicity Pharmaceuticals. Dr. Craves earned a B.S. in biology from Georgetown University, M.S. in biochemical pharmacology from Wayne State University and Ph.D. in pharmacology and experimental toxicology from the University of California in San Francisco.

Job Titles:

• Director

Jim Daly has over 30 years of experience leading U.S. and global businesses in the biopharmaceutical industry and currently serves as a Director of Acadia Pharmaceuticals, Argenx SE, Bellicum Pharmaceuticals and Halozyme Therapeutics. Most recently, Mr. Daly served as Executive Vice President and Chief Commercial Officer at Incyte Corporation from 2012 to 2015. Previously, Mr. Daly worked for Amgen, Inc. and held various leadership positions over a 10-year period, including his last role as Senior Vice President, North America Commercial Operations, Global Marketing and Commercial Development. Earlier in his career, he spent over 16 years with Glaxo Wellcome/GlaxoSmithKline (GSK) where he held roles of increasing responsibility, including his last role as Senior Vice President, General Manager of the Respiratory and Anti-Infective Business Unit. He earned a B.S. in Pharmacy and an M.B.A. from the University at Buffalo, SUNY.

Job Titles:

• Director

Keith R. Gollust has served on the Board of Directors since July 2016. Previously, Mr. Gollust served as a member of Synta Pharmaceuticals Corp.'s Board of Directors from July 2002 to July 2016 and as Chairman of Synta's Board of Directors from September 2002 to July 2016. Mr. Gollust is a private investor and President of Gollust Management, Inc., the general partner of Wyandanch Partners, an investment partnership. He currently serves on the board of Vindex LLC, a software development company. In the past, Mr. Gollust has served as a director of numerous public and private companies. Mr. Gollust received a B.A. from Princeton University and an M.S.I.A. from Carnegie Mellon University.

Job Titles:

• Director

Kenneth M. Bate has served on the Board of Directors since July 2016. Previously, Mr. Bate was the President and Chief Executive Officer of Archemix Corp., a privately held biopharmaceutical company, and NitroMed, Inc. a public pharmaceutical company. From 2002 to 2005, Mr. Bate served as head of commercial operations and chief financial officer at Millennium Pharmaceuticals, Inc., a biopharmaceutical company. Prior to joining Millennium, Mr. Bate co-founded JSB Partners, LLC, a banking and advisory services firm for biopharmaceutical and life sciences companies. From 1990 to 1996, Mr. Bate was employed with Biogen, Inc., a public biotechnology company, first as its chief financial officer and then as head of the commercial organizations. Mr. Bate currently serves on the board of AVEO Pharmaceuticals, Inc., Astrix Therapeutics, Inc., Genocea Biosciences, Inc. and Epizyme, Inc., each a public biopharmaceutical company. During the last five years, Mr. Bate also served as chairman of the board of Cubist Pharmaceuticals, Inc. and as a director of BioMarin Pharmaceutical Inc. and Vanda Pharmaceuticals, Inc. He holds a B.A. in Chemistry from Williams College and an M.B.A. from The Wharton School of the University of Pennsylvania.

Job Titles:

• Senior Vice President, Business & Corporate Development

Dr. Motesharei has over 20 years of industry experience focused on business and corporate development transactions including therapeutic product licensing and alliances, R&D collaborations, commercial product partnerships, royalty financing and M&A. Prior to joining Madrigal, Dr. Motesharei was Chief Business and Strategy Officer at NeuBase Therapeutics. Since 2004, he has held similar positions with Akcea Therapeutics, EMD Serono (Merck KGaA), Dyax Corporation, Genfit, and Activx Biosciences.

Job Titles:

• Chairman
• Chief Executive Officer
• Member of the Leadership Team

Dr. Friedman has more than 40 years of development and commercial pharmaceutical experience. He is the former CEO of Incyte Pharmaceuticals, former president of DuPont Pharmaceuticals and a former Associate Professor of Medicine & Pharmacology at Harvard Medical School. Dr. Friedman is a diplomat of the American Board of Internal Medicine and he also serves on the Board of Directors of Prelude Therapeutics (Nasdaq: PRLD). Paul A. Friedman, M.D. has served as Chairman of the Board of Directors and as Chief Executive Officer since July 2016. Dr. Friedman served as a member of Synta Pharmaceuticals Corp.'s Board of Directors from March 2014 until April 2016. Dr. Friedman served as the Chief Executive Officer and a Director of Incyte Corporation from November 2001 until his retirement in January 2014. From 1994 to 1998, he served as President of Research & Development for the DuPont-Merck Pharmaceutical Company, and from 1998 to 2001, as President of DuPont Pharmaceuticals Research Laboratories, a wholly-owned subsidiary of the DuPont Company. From 1991 to 1994, he served as Senior Vice President at Merck Research Laboratories. Prior to his tenures at Merck and DuPont, Dr. Friedman was an Associate Professor of Medicine and Pharmacology at Harvard Medical School. Dr. Friedman is a diplomat of the American Board of Internal Medicine and a member of the American Society of Clinical Investigation. Dr. Friedman currently sits on the Board of Directors of Prelude Therapeutics, a publicly traded pharmaceutical company, and Gliknik, Inc. Dr. Friedman received his A.B. in Biology from Princeton University and his M.D. from Harvard Medical School.

Job Titles:

• Member of the Leadership Team
• Director, Founder, Chief Medical Officer and President of Research & Development

Dr. Taub has more than 20 years of experience leading drug development, including roles as Senior Vice President of R&D at VIA Pharmaceuticals, Vice President of Metabolic Disease Research at Hoffmann-La Roche, and leadership roles at Bristol Myers Squibb and DuPont Pharmaceuticals. She was also tenured Professor of Genetics and Medicine at the University of Pennsylvania and a Howard Hughes Investigator. Rebecca Taub, M.D. has served as Chief Medical Officer and Executive Vice President, Research & Development and as a member of our Board of Directors since July 2016. Previously, she served as Chief Executive Officer and as a member of the Board of Directors of privately-held Madrigal Pharmaceuticals, Inc. from inception through its merger with Synta Pharmaceuticals Corp. Prior to joining Madrigal, Dr. Taub served as Senior Vice President, Research & Development of VIA Pharmaceuticals from 2008 to 2011 and as Vice President, Research, Metabolic Diseases at Hoffmann-La Roche from 2004 to 2008. In those positions, Dr. Taub oversaw clinical development and drug discovery programs in cardiovascular and metabolic diseases including the conduct of a series of Phase I and II proof of conduct clinical trials. Dr. Taub led drug discovery including target identification, lead optimization and advancement of preclinical candidates into clinical development. From 2000 through 2003, Dr. Taub worked at Bristol-Myers Squibb Co. and DuPont Pharmaceutical Company in a variety of positions, including Executive Director of CNS and metabolic diseases research. Before becoming a pharmaceutical executive, Dr. Taub was a tenured Professor of Genetics and Medicine at the University of Pennsylvania. Dr. Taub is the author of more than 120 research articles. Before joining the faculty of the University of Pennsylvania, Dr. Taub served as an Assistant Professor at the Joslin Diabetes Center of Harvard Medical School, Harvard University and an associate investigator with the Howard Hughes Medical Institute. Dr. Taub received her M.D. from Yale University School of Medicine and B.A. from Yale College.

Job Titles:

• Chief Commercial Officer
• Member of the Leadership Team

Mr. Sukhija has 25 years of commercial experience in the pharmaceutical industry with a successful track record of building businesses and launching products. Before Madrigal, Mr. Sukhija served as Senior Vice President of North America Commercial Operations at Otsuka Pharma. Prior to that he built and led M&A exit of a venture-backed start-up, Merganser, as Chief Operating Officer. Mr. Sukhija built and led Biogen's hemophilia franchise and held several sales and marketing leadership roles at Pfizer and GSK in the earlier part of his career.

Job Titles:

• Director

Richard S. Levy, M.D. has served on our Board of Directors since August 2016. He also serves on the Board of Directors of Gliknik Corp., a privately held biotechnology company. Previously, Dr. Levy served as Executive Vice President and Chief Drug Development Officer at Incyte Corporation, a publicly held biopharmaceutical company, from January 2009 until his retirement in April 2016, and as Senior Vice President of Drug Development from August 2003 to January 2009. Prior to joining Incyte, Dr. Levy served as Vice President, Biologic Therapies at Celgene Corporation, a publicly held biopharmaceutical company, from 2002 to 2003. From 1997 to 2002, Dr. Levy served in various executive positions with DuPont Pharmaceuticals Company, first as Vice President, Regulatory Affairs and Pharmacovigilence, and thereafter as Vice President, Medical and Commercial Strategy. Prior to DuPont / DuPont Merck, Dr. Levy worked at Novartis and its predecessor company, Sandoz, in positions of increasing responsibility in clinical research and regulatory affairs. Dr. Levy has more than 25 years' experience in the pharmaceutical and biotechnology industries through his prior positions at Celgene, DuPont Pharmaceuticals and Novartis, has extensive clinical research, regulatory and product development skills and has worked in multiple therapeutic areas. Prior to joining the pharmaceutical industry, Dr. Levy served as an Assistant Professor of Medicine at the UCLA School of Medicine. Dr. Levy is Board Certified in Internal Medicine and Gastroenterology and received his A.B. in Biology from Brown University, his M.D. from the University of Pennsylvania School of Medicine and completed his training in Internal Medicine at the Hospital of the University of Pennsylvania and a fellowship in Gastroenterology and Hepatology at UCLA.

Job Titles:

• Member of the Leadership Team
• Chief Pharmaceutical Development Officer

Dr. Waltermire brings proven expertise in all aspects of chemistry, manufacturing and control (CMC), as well as experience in manufacturing new commercial products. Most recently, Dr. Waltermire served as Senior Vice President, CMC at VenatoRx. From 1988 to 2020, Dr. Waltermire held positions of increasing responsibility at Bristol-Myers Squibb (BMS) and Dupont Pharmaceutical Company, including Vice President Chemical and Synthetic Development at BMS.

Dr. Dodge has over 20 years of medical affairs leadership across both small biotech and large pharma, including roles at Intercept, Merck, Novo Nordisk and Novartis. He has more than 10 years working directly in hepatology and GI, as well as metabolic disease, building out medical affairs capabilities to support market entry in new therapeutic areas across 20+ launches.

Job Titles:

• Senior Vice President, Clinical Management

Mr. Hare has more than 30 years of clinical development and management experience in the biopharmaceutical and contract research organization industries. He is the former Senior Vice President of Product Development at Advaxis, Inc. and has also held senior management positions at Incyte Pharmaceuticals and Premier Research.