CENTRAL SYDNEY CARDIOLOGY - Key Persons

Lattimore J.D., Wilcox I, Skilton M, Langenfeld M, Celermajer DS. Treatment of obstructive sleep apnoea leads to improved microvascular endothelial function in the systemic circulation.

Job Titles:

• Consultant Cardiologist

Wilcox I, Freedman SB, Allman KC, Collins FL, Leitch JW, Kelly DT, Harris PJ. The prognostic significance of a pre-discharge exercise test in risk stratification after unstable angina pectoris. Journal of theAmericanCollege of Cardiology 1991;18:677-83 [Editorial: Vagaries of predischarge exercise stress testing in acute myocardial ischemic syndromes. Ferlinz J. pp 684-6]

Job Titles:

• Cardiologist ( VMO ), Royal Prince Alfred Hospital / Cardiologist, Strathfield Private Hospital / Research Fellow, Sydney Marfan and Aortic Disease Clinic

Dr Elizabeth Robertson completed post-graduate medical degree from the University of Sydney in 2006. Prior to this she completed an honours degree in biomedical science at the University of Newcastle (Aus) with a focus on molecular biochemistry. Dr Robertson has subsequently completed her post-graduate specialist training in cardiology at Royal Prince Alfred Hospital. During her training, Dr Robertson has had ongoing involvement in research with the Sydney Marfan and Aortic service under the supervision of Professor Richmond Jeremy. She is currently completing her PhD in medicine, with the aim of further characterising the molecular mechanisms that underlie the inherited aortic disease. Dr Elizabeth Robertson completed post-graduate medical degree from the University of Sydne... read more

Job Titles:

• Staff Specialist Cardiology, Royal Prince Alfred Hospital / Network Director of Physician Training, Royal Prince Alfred Hospital

Hunyor I, Cook., K. Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer, AJP: Regulatory, Integrative and Comparative Physiology. 2018;315(4):R669-R687. Dr Imre Hunyor completed his medical degree with honours at the University of Sydney following a degree in Advanced Science. He was awarded a Rhodes Scholarship and completed his doctorate at the University of Oxford. His primary research was in the field of cardiac energetics, metabolism and heart failure under the supervision of Professor Stefan Neubauer. He was based in the Department of Cardiovascular Medicine at the Wellcome Trust Centre for Human Genetics. His subsequent specialty training in Cardiology and subspecialty training in Cardiac MRI, CT and Echocardiography was at the Royal Prince Alfred Hospital. Dr Hunyor's primary research interest includes the application of multimodal cardiac imaging to non-invasively interrogate the heart's structure, function and biochemistry. His clinical interests include all aspects of general cardiology with an interest in arrhythmia, cardiomyopathy and valvular heart disease. His imaging expertise supports services in arrhythmia, congenital, genetic and structural heart disease, including minimally invasive interventions. Dr Hunyor is a Clinical Senior Lecturer at the University of Sydney Medical School. He holds an appointment as a Staff Specialist Cardiologist at Royal Prince Alfred Hospital and has Level III CMR Certification, Society for Cardiovascular Magnetic Resonance as well as being a Certified Established Provider in Cardiac MRI, RANZCR. As the Network Director of Physician Training/Director of Medical Education he oversees the training program for Basic Physician Trainees and is an Examiner for the RACP.

Job Titles:

• Structural Heart Interventional Cardiologist

Dr Jordan Fulcher graduated from the University of New South Wales in 2003 and completed his cardiology specialty training at Royal Alfred Hospital in 2013. He completed a Masters in Clinical Trials Research in 2015 and submitted his PhD on statins, cholesterol and the risk of cardiovascular disease at the University of Sydney in late 2016. He is involved in ongoing research in the same field at the NHMRC Clinical Trials Centre at the University of Sydney. Dr Fulcher has an active involvement in teaching, including lecturing and assessment for the Masters of Metabolic Health course at Sydney University, PBL tutoring for Sydney Medical School and summer scholarship student supervision at the NHMRC Clinical Trials Centre. He is a regular speaker at GP educational meetings. Dr Fulcher currently works as a VMO cardiologist at Strathfield Private Hospital and is an Honorary VMO at Royal Prince Alfred Hospital. He has worked regionally in Orange and Coffs Harbour as a locum consultant and VMO cardiologist over the last several years. He is fellow of the Royal Australasian College of Physicians and an associated member of the Cardiac Society of Australia and New Zealand. Dr Jordan Fulcher graduated from the University of New South Wales in 2003 and completed his cardiology specialty traini... read more

Job Titles:

• Cardiologist
• Staff Specialist Cardiologist, Royal Prince Alfred Hospital

Dr Chan is a Cardiologist with subspecialty training in Cardiac Electrophysiology (Heart Rhythm Disorders). He has completed National Heart Foundation funded PhD studies on vascular disease at the University of Sydney, followed by a 2 year postdoctoral clinical and research fellowship in Cardiac Electrophysiology at Loyola University Medical Center, Chicago, USA, under the mentorship of Prof David Wilber, before returning to Australia as a Staff Specialist in Cardiology and Cardiac Electrophysiology at Royal Prince Alfred Hospital and Senior Clinical Lecturer at the University of Sydney Medical School. Dr Chan is actively involved in research and has published extensively in peer-reviewed journals. Dr Chan evaluates patients with palpitations and loss of consciousness, treats all aspects of heart rhythm disorders, and performs a range of procedures including electrophysiology studies, catheter ablation of atrial fibrillation, atrial flutter, supraventricular tachycardia, ventricular tachycardia, and pacemaker and defibrillator implantation. Dr Chan is a cardiologist with an interest in heart rhythm disorders, pacing and implantable cardiac devices. He complet... read more

Job Titles:

• Staff Member

Dr Lucy Geraghty completed her Bachelor of Medicine Bachelor of Surgery (MBBS) with First Class Honours and awards for academic excellence at the University of Sydney. She completed Basic Physician Training and Cardiology Advanced Training at Royal Prince Alfred Hospital. Lucy is a general cardiologist. She has a sub-speciality interest in multi-modal cardiac imaging and is currently undertaking a fellowship in cardiac cross-sectional imaging at Royal Prince Alfred Hospital. Lucy has also completed her American Society of Echocardiography board certification examination. Lucy is dedicated to teaching medical students and doctors in training. She holds a position as a Clinical Lecturer at the University of Sydney and as an Associate Education Coordinator with the RPA Basic Physician Training program. Dr Lucy Geraghty completed her Bachelor of Medicine Bachelor of Surgery (MBBS) with First Class Honours and awards for a... read more

Job Titles:

• Honorary Medical Officer, Royal Prince Alfred Hospital / Visiting Medical Officer, Strathfield Private Hospital

Dr Michelle Lim completed her Bachelor of Medicine Bachelor of Surgery at the University of New South Wales in 2009. She subsequently completed her Basic Physicians Training and Cardiology Advanced Training at the Royal Prince Alfred Hospital. Michelle is a general clinical cardiologist. She has interests in preventative medicine and in the role of cardiac echocardiography, and is currently completing a diploma in diagnostic ultrasound/echo. Michelle is also a PhD candidate at the University of Sydney, studying bicuspid aortic valves and associated aortic disease. Michelle's passion for education is evident, as the course convenor for the Cardiovascular Metabolic Management Unit of study at the Faculty of Medicine and Health, University of Sydney. She is also undertaking a Clinical Teaching Fellowship and is regularly involved in the education of medical students. Dr Michelle Lim completed her Bachelor of Medicine Bachelor of Surgery at the University of New South Wales in 2009. She... read more

Job Titles:

• ANZET Early Career Research Prize
• Interventional Research Fellow, Royal Prince Alfred and Concord Repatriation General Hospital

Dr Rajan Rehan completed his undergraduate medical training from Bond University, followed by a Master of Public Health at the University of New South Wales. He subsequently completed his basic physician training and speciality cardiology training at Royal Prince Alfred Hospital. Dr Rehan has a particular interest in coronary artery disease and structural heart interventions. He is currently an interventional research fellow at Royal Prince Alfred and Concord Repatriation General Hospital whilst completing his PhD at the University of Sydney. His research is focused on novel mechanisms involved in non-obstructive coronary artery disease. Furthermore, he is completing subspecialty training in multimodality imaging, including Cardiac MRI, CT and Echocardiography. He also serves as a clinical lecturer at the University of Sydney with regular involvement in medical student teaching. Dr Rajan Rehan completed his undergraduate medical training from Bond University, followed by a Master of Public Health ... read more

Michele McGrady, Christopher M Reid, Louise Sheil, Rory Wolfe, Umberto Boffa, Danny Liew, Duncan J Campbell, David Prior, Henry Krum. NT-ProB natriuretic peptide and the association to left ventricular diastolic function in a population at high risk of incident heart failure: Results of the SCReening Evaluation of the Evolution of New - Heart Failure Study (SCREEN-HF). European Journal of Heart Failure 2012; in press.

Job Titles:

• CEO, the George Institute for Global Health / Executive Director, the George Institute India / Professor of Medicine, University of Sydney
• Professor
• Professor at UNSW Sydney

Professor Anushka Patel no longer consults at Central Sydney Cardiology and can be contacted through The George Institute for Global Health. Professor Anushka Patel is a Scientia Professor at UNSW Sydney, CEO of The George Institute for Global Health and an honorary cardiologist at Royal Prince Alfred Hospital. She completed her undergraduate medical training at the University of Queensland in 1989, and her training in cardiology (leading to Fellowship of the Royal Australian College of Physicians) in Sydney. She has a Master of Science degree in Epidemiology from Harvard University and a PhD in Medicine from the University of Sydney. Both in her research and clinical practice, Professor Patel has a particular focus on preventive cardiovascular care. She currently holds a National Health & Medical Research Council Principal Research Fellowship. Professor Anushka Patel is a Scientia Professor at UNSW Sydney, the Vice-Principal Director and Chief Scientist of The G... read more

Job Titles:

• Cardiologist, Royal Prince Alfred Hospital ( Senior VMO ) Clinical Professor, Sydney Medical School, University of Sydney / Cardiologist, Strathfield Private Hospital
• Professor

Wilcox I, Chan KH, Dimitri H. Diagnosis and treatment of obstructive sleep apnea is key to achieving optimal results after catheter ablation of atrial fibrillation. J Am Coll Cardiol. 2014;63(6):607-8. Wilcox I, Semsarian C. Obstructive sleep apnea: a respiratory syndrome with protean cardiovascular manifestations. (Editorial) Journal of the American College of Cardiology 2009;54:1810-11 Professor Ian Wilcox was born in Melbourne and undertook medical training in Newcastle on Tyne (UK), including a BMedSci... read more Professor Ian Wilcox was born in Melbourne and undertook medical training in Newcastle on Tyne (UK), including a BMedSci with First Class Honours in Immunology. His postgraduate education and training in Cardiology was at Sydney University and Royal Prince Alfred Hospital. Professor Wilcox's clinical research career includes a PhD on Predicting Risk in Unstable Angina funded by a National Heart Foundation Scholarship. His postdoctoral research on the Cardiovascular Consequences of Obstructive Sleep Apnoea was funded by the National Health and Medical Research Council in collaboration with Professor Colin Sullivan. He has supervised 8 PhD and Masters Students. Current research interests include the role of sleep apnoea in cardiac arrhythmias, congestive heart failure, large vessel vascular disease and atherosclerosis. He has over 40 publications in major journals and 1200 citations in the medical literature. In addition he has a major interest in innovation in clinical research and practice in cardiology including new methods to detect heart failure decompensation. Professor Wilcox jointly established the Cardiac Surgery Program at Strathfield Private Hospital in 1991 and founded Central Sydney Cardiology, an academic private practice, in 1999.

Job Titles:

• Associate Professor
• Clinical Associate Professor

Associate Professor Jo-Dee Lattimore graduated in medicine at the University of Otago in 1992, undertook basic physician training at Westmead Hospital and completed cardiology training at Royal Prince Alfred Hospital in 2000.

Job Titles:

• Professor
• Professor of Cardiometabolic Medicine, School of Medical Sciences, Faculty of Medicine and Health, the University of Sydney

Professor John O'Sullivan is a Clinical-Academic Cardiologist specialising in Heart Failure. He is the inaugural Profe... read more Professor John O'Sullivan is a Clinical-Academic Cardiologist specialising in Heart Failure. He is the inaugural Professor of Cardiometabolic Medicine at the University of Sydney and Department of Cardiology, Royal Prince Alfred Hospital. He is a Level 2 NHF Future Leader Fellow, and co-Director of the HFpEF ("Stiff Heart Failure") Clinic at RPAH. He is Director of the Heart Failure Alliance across SLHD and WSLHD, incorporating RPAH, Concord, Westmead, and Blacktown Hospitals. John is Lead Principal Investigator on two clinical trials in HFpEF: CardioNAD (ACTRN12622000340730) at RPAH, and pEFNAD (ACTRN12622000372785) across the Heart Failure Alliance, which are extensions of his discoveries in the laboratory. John is an international expert in heart failure bioenergetics, whose expertise is sought internationally by national grant bodies, in addition to medical and cardiac societies. John's clinical practice at Central Sydney Cardiology focusses on Heart Failure and Early Prevention of Atherosclerotic Cardiovascular Disease (ASCVD). John's discoveries have been translated to clinical biomarkers, Medicare Item Numbers, and new diagnostic assays. John completed his medical and cardiology training in Ireland, the USA, and Australia, and spent 4 years on a postdoctoral fellowship at Massachusetts General Hospital, Harvard Medical School, and the Broad Institute of Harvard and MIT. After foundational clinical training in cardiology, subspecialising in Heart Failure, he undertook a PhD in cardiovascular physiology, and then postdoc specialist training in metabolomics, functional genomics, and bioenergetics. John's PhD work was awarded with Young Investigator Awards at the Irish Cardiac Society, American College of Cardiology, and American Heart Association (separate projects). John's postdoctoral work was recognised with another Young Investigator Award at the American Heart Association, a Harvard Medical School Tosteson Award, and an MGH Poster of Distinction Award. John has established a bench-to-bedside Heart Failure program of research underpinned by the strong governance structure of his Heart Failure Alliance, incorporating murine models of heart failure, ex vivo Langendorff and Working Heart Cardiac Perfusion models, a human "beating heart slice" model, primary human cardiomyocytes, stable-isotope cardiac substrate tracing, a heart failure biopsy program, a transcardiac heart failure gradient program, and a HFpEF clinic. The Alliance has also incorporated a community and consumer advisory group, health economists, and commercial partnerships obtaining novel tool compounds with promising efficacy in heart failure. In addition to publishing in the most highly ranked biomedical journals, obtaining continuous competitive funding, John has a track record of commercialisation. In 2016 he discovered a novel biomarker (first entered in the Human Metabolome Database in 2017), that received a Medicare Item number and is routinely measured by NSW Health Pathology. John's expertise has been sought by the Medical Research Councils of the EU, UK, Norway, and New Zealand, and he is a Member of the Novel Cardiovasular Risk Assessment Expert Subgroup reporting to the Australian Department of Health. John is committed to improving the lives of patients living with heart failure. John has clinical and research interests in heart failure, particularly Heart Failure preserved Ejection Fraction (HFpEF), a type of heart failure that now accounts for more than half of all heart failure cases, but for which there are no treatments. He uses a range of tools to study this disease, including cardiac MRI. Employing new insights from his HFpEF research program, he aims to offer the most up-to-date, evidence-based therapeutic strategies to help patients with this disease. John has a strong clinical interest in cardiometabolic disease: how unhealthy diet, overweight / obesity, and insulin resistance interact with cardiovascular disease, driving atherosclerosis and heart failure. He also studies the role of the microbiome in these diseases. Cardiovascular prevention, particularly how to employ the latest evidence in dietary science and exercise to prevent and manage cardiovascular disease, is a core focus of John's clinical interests.

Job Titles:

• Associate Professor
• Professor

Kathir K, Dennis J, Croft K, Mori T, Lau A, Adams M, Stocker R. Equivalent lipid oxidation profiles in advanced atherosclerotic lesions of carotid endarterectomy plaques obtained from symptomatic type 2 diabetic and non-diabetic subjects. Free Radical Biology and Medicine, 2010;49(3):481-6 Professor Adams does not consult in our Private Rooms. To arrange a consultation, please contact the Cardiology Department at The Royal Prince Alfred Hospital.

Job Titles:

• Professor
• Professor in Medicine ( Cardiology ), University of Sydney

Professor Jeremy has 20 years experience in diseases of the aorta, particularly inherited aortopathies, such as Marfan syndrome and familial aneurysm syndromes. His work involves close collaboration with the cardiac surgery team at Royal Prince Alfred Hospital in the diagnosis and management of patients with aortic disease. His research interests include mechanisms of aortic aneurysm formation, and clinical management and outcomes of thoracic aortic aneurysm disease. Professor Richmond Jeremy's medical and cardiology training were at the University of Sydney and Royal Prince Alfred Hos... read more

Job Titles:

• Associate Professor

Sean completed his undergraduate degree in Medical Science with first class honours at the University of Sydney, receiving full academic scholarship. He pursued his graduate Medical Degree (MBBS) and a Master of Medicine by research (MPhil) at the University of Sydney, where he was awarded the Dean's Scholarship, the Medical Foundation Scholarship, and the University of Sydney Bercovici Medal. As a medical doctor, Sean completed his general and specialty training at Royal Prince Alfred Hospital. During his cardiology training, he was awarded a National Churchill Fellowship to study mechanisms of cardiac regeneration at Harvard Medical School. Sean has clinical and research training in heart failure. For his PhD in this field, he was awarded a combined National Health and Medical Research Council (NHMRC) and National Heart Foundation (NHF) Scholarship, as well as the NHMRC and Royal Australasian College of Physicians (RACP) prize for research excellence. Sean was awarded a Commonwealth Endeavour Postgraduate Fellowship to Harvard Medical School and Massachusetts Institute of Technology (MIT), where he undertook proof of concept studies demonstrating the intrinsic regenerative capacity of the human heart, whilst also gaining clinical experience in acute heart failure management in the cardiac ICU at the Brigham and Women's Hospital. Sean is the Director of the Sydney Heart Bank, which is the largest biorepository of cryopreserved human heart tissue in the world. He is the Head of the Cardiac Research Laboratory in the School of Medical Sciences at the Charles Perkins Centre, which focuses on basic science and translational research into the molecular pathways of human heart failure, ageing and cardiac regeneration. 18. Sean Lal, Amy Li and Cris dos Remedios. Limitations in translating animal studies to humans in cardiovascular disease. (2016) Journal of Cardiovascular Translational Research April 9(2): 165-6 27. Ranganath Mamidi, Jiayang Li, Kenneth S. Gresham, Chang Yoon Doh, Amy Li, Sean Lal, Cristobal G. dos Remedios and Julian E. Stelzer. Dose-dependent effects of the myosin activator omecamtiv mecarbil on cross-bridge behavior and force generation in failing human myocardium. (2017) Circulation Heart Failure Oct; 10(10) 1-11 29. Sean Lal, Irina Kotchetikova, Jacob Cao, Daniel Jackson, Rachael Cordina and David S Celermajer. Heart failure admissions and poor subsequent outcomes in adults with congenital heart disease. (2017) European Journal of Heart Failure Apr;20(4):812-815. 34. Nelson Wang, Jordan Fulcher, Nishan Abeysuriya, Michele McGrady, Ian Wilcox, David Celermajer, Sean Lal. Tricuspid Regurgitation is associated with increased mortality independent of pulmonary pressures and right heart failure. (2019) European Heart Journal 40, 476-484. This article was editorialised European Heart Journal (2019) 40, 485-487. 37. Sean Lal and Bernhard Kuhn. Regenerating hearts by arresting development with hypothyroidism. (2019) Circulation Research. 124:1725-1726. 44. Mark Dennis, Sean Lal, Paul Forrest, Alistair Nichol, Lionel Lamhaut, Richard Totaro, Brian Burns, Claudio Sandroni. Extracorporeal cardiopulmonary resuscitation in adult out of hospital cardiac arrest: A contemporary review. (2020) Journal of the American Heart Association. 56. Shannon Chiang, Nady Braidy, Sanaz Maleki, Sean Lal, Des Richardson, Michael Huang. Mechanisms of impaired mitochondrial homeostasis and NAD metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation. (2021) Redox Biology Oct; 46:102038.

Wilcox I, McNamara SG, Dodd MJ, Sullivan CE. Ventilatory control in patients with sleep apnoea and left ventricular dysfunction: comparison of obstructive and central sleep apnoea. European Respiratory Journal 1998;11:7-13 [Editorial: Augmented chemosensitivity to hypercapnia: another link in our understanding of the pathogenesis of Cheyne-Stokes respiration.

hRUV: Hierarchical approach to removal of unwanted variation for large-scale metabolomics data Taiyun Kim^, Owen Tang^, Stephen T Vernon, Katharine A Kott, Yen Chin Koay, John Park, David James, Stuart M. Grieve, Terence P Speed, Pengyi Yang+, Gemma A Figtree+, John F. O'Sullivan+, Jean Yee Hwa Yang+. +joint senior authors Nature Communications 2, 4992 (2021). https://doi.org/10.1038/s41467-021-25210-5 Effect of chronic exercise in healthy young male adults: a metabolomic analysis. Yen Chin Koay, Kelly Stanton, Vivian Kienzle, Mengbo Li, Jean Yang, David S. Celermajer, John F. O'Sullivan. Cardiovasc Res. 2021 Jan 21;117(2):613-622. pii: cvaa051. doi: 10.1093/cvr/cvaa051. PMID: 32239128