POWERS

Based on the success of the Human Genome project and the Structural Genomics initiatives, thousands of functionally uncharacterized proteins have been identified. Sequence and structural similarity techniques may provide functional information for, at most, half of these proteins. To functionally annotate all known proteins will require the development of new techniques and methodology to rapidly determine protein structures and evaluate protein function. By combining the strengths of NMR, mass spectrometry and molecular modeling, rapid approaches to solving both protein and protein-ligand complexes are being explored in our group. Additionally, by modifying NMR screening techniques utilized to identify drug candidates, we are exploring the ability to quickly ascertain initial functional information for functionally uncharacterized proteins that have emerged from the Structural Genomics effort. Toward this end, we have developed the FAST-NMR technology that incorporates structural..

Also known as: Powers Group