OCMR - Key Persons
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- Clinical Research Fellow and DPhil Student
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- Royal Society University Research Fellow
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- Professor of Interventional Cardiology
I perform translational research into mechanisms of injury in PCI and understanding reperfusion in ST elevation myocardial injury. Initially we demonstrated the importance of Troponin elevation after PCI as it reflects new myocardial injury detected by MR imaging. . We then investigated changes in blood flow in these newly injured areas and investigated the impact of opening chronic occlusions on myocardial function.
We completed a randomised controlled trial of PCI vs CABG with evidence of new myocardial injury as the endpoint (Eurointervention January 2011). Analysis of the role of different markers of injury in this study was published by J Am Coll Cardiol 2011 with an accompanying editorial. This work helped change the biochemical definitions of revascularisation injury within subsequent trials of revascularisation strategy.
We are currently investigating how to predict outcome in ST elevation myocardial infarction and how using these novel tools we might tailor therapy for those patients most at risk of adverse outcomes.
Job Titles:
- Visiting Postdoctoral Clinical Researcher
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- Clinical Research Fellow & DPhil Student
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- Professor of Human Genetics
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- Associate Professor of Cardiovascular Genetics
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- Senior Research Associate
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- British Heart Foundation ( BHF ) Professor of Cardiovascular Medicine
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- Associate Professor of Cardiovascular Medicine
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- British Heart Foundation Chair of Cardiovascular Medicine
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- Head of Genome Engineering / Principal Investigator in RDM
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- University Research Lecturer
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- Professor of Physiological Metabolism
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- Cardiovascular Medicine and Head of .
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- Professor of Metabolic Medicine
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- Professor of Stroke Medicine
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- Associate Professor of Cardiovascular Science
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- Associate Professor of Haematology
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- Professor of Iron Biology
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- Head of Clinical Research Operations and Governance
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- Consultant Medical Virologist & Principal Investigator
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- Visiting Professor of Experimental Therapeutics
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- Senior Postdoctoral Researcher
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- Academic Clinical Lecturer, Division of Cardiovascular Medicine
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- Professor of Molecular Haematology
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- Senior Bioinformatics / Data Scientist
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- Associate Professor of Genomics
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- Associate Professor of Geratology & Stroke Medicine
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- Academic Foundation Doctor
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- British Heart Foundation Clinical Research Fellow & DPhil Student
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- Associate Professor of Microbiology and Hospital Epidemiology
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- Field Marshal Earl Alexander Professor of Cardiovascular Medicine and Head of Department
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- Clinical Research Fellow in Cardiology
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- Associate Professor of Metabolic Imaging
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- Professor of Metabolic Physiology
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- Associate Professor of Haematology and Transfusion Medicine
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- Professor of Developmental Haematopoiesis
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- Associate Professor of Cardiovascular Medicine
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- British Heart Foundation Clinical Research Training Fellow & DPhil Student
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- Associate Professor in Medical Virology / Consultant in Infection
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- ASSOCIATE PROFESSOR of CARDIOVASCULAR SCIENCE
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- Associate Professor of Haematology
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- Director of Oxford Islet Isolation and Islet Transplant Programmes and
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- Postdoctoral Research Assistant
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- Clinical Research Practitioner
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- Professor of Stroke Medicine
Prof Alastair Buchan heads the Laboratory of Cerebral Ischaemia whose aim is to identify novel neuroprotective strategies that may be used for the treatment or prevention of an acute stroke. We conduct preclinical studies on putative neuroprotectants in models of stroke, while running human studies to identify potential targets for treatment strategies and markers for monitoring patients. We take a multimodal approach that involves aspects of cell and molecular biology, physiology, pharmacology, in vivo imaging, surgery and clinical medicine. Our interests currently lie in many exciting avenues of stroke research. We are identifying and targeting novel neuroprotective pathways following brain ischaemia such as the oxygen sensing mechanism, hypoxia inducible factor (HIF). We are also using proteomic and metabolomic techniques to identify new biomarkers for stroke. Other avenues of research include investigating neurovascular coupling following stroke, exploring pericyte control of capillary blood flow as well as attempting to improve the efficacy of the only approved treatment for acute stroke, recombinant tissue plasminogen activator (rtPA).
Job Titles:
- RDM Principal Investigator
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- Professor of Clinical Genetics
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- Postgraduate Research Assistant
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- Professor of Diabetic Medicine
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- Professor of Cardiovascular Medicine
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- Professor of Genome Maintenance Biology
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- Cardiology Registrar and Clinical Research Fellow
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- Associate Professor of Cardiovascular Medicine
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- Health Care Assistant ( Research )
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- Professor of Cardiovascular Medicine
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- Professor of Molecular Immunology
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- Postdoctoral Fellow - Stanford University
- Postdoctoral Fellow - Stanford University / Senior Scientist - Immunocore
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- Professor of Cardiovascular Medicine
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- Professor of Biomedical Imaging
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- Professor of Molecular Therapy
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- Postdoctoral Research Scientist
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- Associate Professor of Cardiovascular Medicine
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- Professor of Cardiovascular Medicine
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- Associate Professor of Neuroimmunology
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- BHF Clinical Research Training Fellow