QUANTBIOLOGY.ORG

We use proteomics approaches to study cellular signaling processes and drug response. These include the use of chemoproteomics tools like kinobeads to enrich kinases and their interacting partners in cell or tissue lysates. We use these enriched kinomes to measure the activity of signaling pathways to study the response of these cells and tissues to specific drugs. Our laboratory focuses on developing and applying novel proteomics approaches to measure proteome-wide changes in post-translational modifications and protein abundances whilst studying protein-protein interactions that dynamically regulate cellular processes like growth and proliferation (see 'Selected publications' and 'Our research interests'). We are affiliated with the graduate programs in UW Pharmacology, UW Genome Sciences, and the umbrella programs UW MCB and BPSD. Our team includes experts in chemical biology, genetic analysis, genomics, and proteomics and reflects our passion in research that spans different..