SYSTEMS AND COMPUTATIONAL BIOLOGY GROUP

We use computational neuroscience and systems biology approaches to study complex diseases that are known to differentially affect astrocytes. At present we are focused on glioblastoma, fragile X and autism. The goal is to develop an understanding of the role played by astrocytes in relation to the function (and dysfunction) of the entire brain. Questions of interest include studying how these diseases may have created molecular novelties operant in the constituent pathways and what mechanisms are at play in generating these novelties, which could then be studied for their potential as drug-targets... A third research direction in our group is studying the origin and evolution of metabolic, regulatory, and signaling networks and modules at a genome wide level in humans, in model organisms, and in pathogenic bacteria. We integrate comparative genomics, '-omics' data mining, and systems biology approaches to explore comparative evolution of gene networks between organisms... Welcome to..

Primary location: Urbana United States