GLADSTONE - Key Persons
Job Titles:
- Member of the Lab
- Rotation Student
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- Member of the Lab
- Research Associate I
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- Director
- Member of the Scientific Leadership Team
- Named Connie and Bob Lurie Director of the Gladstone - UCSF Institute of Genomic Immunology
- Scientific Director for Biomedicine at the Innovative Genomics Institute
- Senior Investigator and Director, Gladstone - UCSF Institute of Genomic Immunology
Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, explains that the Billion Cells Project, for which he is a collaborator, will provide a roadmap to guide drug development…
Alex Marson, director of the Gladstone-UCSF Institute of Genomic Immunology, is featured for his innovative work using CRISPR genome editing to develop better cellular therapies for cancer, silencing…
Marson serves as the scientific director for biomedicine at the Innovative Genomics Institute, founded by Nobel laureate Jennifer Doudna. He is a director of the Parker Institute for Cancer Immunotherapy at Gladstone Institutes and was chosen one of the inaugural investigators at the Chan Zuckerberg Biohub. Marson also co-founded Arsenal Bio, Site Tx, Survey Genomics, and Spotlight Therapeutics, and he serves on the scientific advisory boards for Amgen, NewLimit and Tenaya Therapeutics.
Alexander Pico received his undergraduate degree from the University of Oregon, and his PhD in molecular neurobiology and biophysics from Rockefeller University. He first joined Gladstone in 2004 as a postdoctoral fellow in the laboratory of Bruce Conklin, where he focused on bioinformatics and software development.
Since then, Pico has established himself as an international leader in systems biology technology. In 2007, he conceived of and co-founded WikiPathways, an open, collaborative platform for molecular pathway curation. In 2010, he took on leadership roles in the Cytoscape Consortium as vice president and as executive director for the National Resource for Network Biology. In addition to his independent research, he has served as the director of the Gladstone Bioinformatics Core since 2020.
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- Graduate Student
- Visiting Scientist
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- Director of the Roddenberry Foundation
- Trustee in 2004
Garb first became involved with Gladstone in 1981 when he was named legal counsel to the Gladstone trustees, and in 1995 he became trustee designate. In 2022, Garb retired from the law firm Loeb & Loeb LLP in Los Angeles, where he had been the managing partner from 1986 to 1992. At Loeb & Loeb, Garb's clients included J. Paul Getty, Jr., the Conrad Hilton Foundation, the William Randolph Hearst Trust, and the estates of Gene Roddenberry and Frank Sinatra. As a fellow of the American College of Trust and Estate Counsel, he published and lectured extensively in the field of trust and estate law.
Garb is currently the director of the Roddenberry Foundation, a director of the Kane Educational and Research Foundation, and a director of Whittier Trust Company. He previously served as chair of the board and co-founder of Success Through the Arts Foundation, president of the board of the greater Los Angeles chapter of the Crohn's and Colitis Foundation, and was a member of its National Grants Review Committee.
Garb earned a JD at Harvard Law School in 1967. Following a teaching/research assistantship at Yale Law School, he received his LLM from the University of Southern California Law School.
Job Titles:
- Assistant
- Assistant Investigator
Andrew Yang, PhD, is an assistant investigator at Gladstone Institutes, and an assistant professor in the Departments of Neurology and Anatomy at UC San Francisco (UCSF). Yang earned a BS in mechanical engineering and materials science from the Massachusetts Institute of Technology and a PhD in bioengineering from Stanford University, where he trained in the neuroscience laboratory of Gladstone alumnus Tony Wyss-Coray. He joined UCSF as a Sandler Faculty Fellow in the Bakar Aging Research Institute and the Department of Anatomy in January 2022, and Gladstone in 2023.
Yang applies his training in engineering and his curiosity about neuroscience toward understanding the meaning, mechanisms, and therapeutic potential of protein and immune cell messages at the critical interface where the brain interfaces with the blood. His research has shown an unexpected degree of communication across the blood-brain barrier and has revealed a critical role for this barrier in the development of Alzheimer's disease.
Job Titles:
- Member of the Scientific Leadership Team
- Vice President of Communications
- Member of the Public Relations Society of America
Anna-Marie Rooney is the vice president of communications at Gladstone Institutes. She possesses more than 30 years of experience helping leading nonprofit organizations increase their marketing capacity and brand awareness, with an emphasis in the area of scientific and translational research.
Rooney is a member of the Public Relations Society of America, the American Marketing Association, and Athena. A Colorado native, she earned her degree in communications with an emphasis on marketing and public speaking from the University of Denver.
Job Titles:
- Member of the Core Advisory Board
- Member of the National Academy of Sciences
Sharpe is an elected member of the National Academy of Sciences, National Academy of Medicine, National Academy of Inventors, and the American Academy of Arts and Sciences. She is also a member and past president of the American Association of Immunologists.
Job Titles:
- Member of the Lab
- Research Associate I
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- Senior Investigator
- Fellow of the International Society for Computational Biology
- Senior Investigator at Gladstone Institute
Barbara Engelhardt works to improve human health by analyzing the enormous reams of data generated by research labs, doctors, and hospitals. Combining mathematical, statistical, and artificial intelligence approaches, her team seeks to understand the cellular mechanisms of disease, the impact of traumatic life events on health, and the clinical treatments that best correlate with positive health outcomes. The team anchors their work in a large network of collaborations, and generates computational and statistical tools aimed at increasing the impact of both medical research and healthcare practice.
Barbara Engelhardt has been tackling these challenges with a combination of statistics and machine learning approaches. Her analysis of electronic health care data has led to a policy for weaning patients from a mechanical ventilator, and another that reduced the number of blood draws for hospital tests by 40 percent and accelerated the diagnosis of sepsis by approximately four hours.
Her work in genomics seeks to understand the genetic basis for complex traits and the cellular mechanisms underlying this relationship. Complex traits, including many diseases, manifest as a continuum of symptoms that reflect dysregulation among cell types, genes, and other factors. Engelhardt has developed tools to explore, identify, and quantify these interactions in large genomic datasets, and to predict the impact of specific interventions. In particular, she is pursuing approaches to incorporate the quantitative output of genes (how much RNA they produce) into her analysis of complex traits, which has led her to identify a gene that protects from muscular myopathy in the context of statin treatment. She is also developing tools to extract biological or disease-relevant information from time series gene expression data, and to identify optimal gene markers to improve the analysis of omic data from single cells.
The ISCB Fellows program is a prestigious recognition within the field of computational biology honoring those who have made outstanding contributions to the discipline. These distinguished…
Barbara Engelhardt, PhD, is a senior investigator at Gladstone Institutes. She is also a professor in the Department of Biomedical Data Science at Stanford University.
Engelhardt opened her lab at Gladstone in 2021. Prior to joining Princeton in 2014, she was an assistant professor in biostatistics and bioinformatics and statistical sciences at Duke University. She graduated from Stanford University, received her PhD in electrical engineering and computer science from UC Berkeley, supported by an NSF Graduate Research Fellowship, and trained as a postdoctoral researcher at the University of Chicago. Engelhardt also spent 2 years working at Jet Propulsion Laboratory, a summer at Google Research, and a year at 23andMe.
Her research interests involve developing statistical models and methods for the analysis of high-dimensional biomedical data, with a goal of understanding the underlying biological mechanisms of complex phenotypes and human disease.
Engelhardt received the 2021 Overton Prize from the International Society for Computational Biology, one of the top awards in this field.
Job Titles:
- Leader
- Member of the Scientific Leadership Team
- Senior Investigator
- Director of the Gladstone Institute of Cardiovascular Disease
- Editor for the Journal Development
- Senior Investigator and Director, Gladstone Institute of Cardiovascular Disease
Bruneau, director of the Gladstone Institute of Cardiovascular Disease, shares exciting recent advances in heart research and talks about the impact of predictive AI.
Senior Investigator Benoit Bruneau describes his lab's recent work, including their use of stem cells to model and and understand congenital heart diseases, their investigation of the role of ¦
Benoit Bruneau is selected to lead the Gladstone Institute of Cardiovascular Disease
Benoit Bruneau is an internationally recognized leader in the field gene regulation. To that, he adds expertise in the potential within stem cells to develop into diverse types of cells, and chromatin, which packages DNA into compact structures. In his lab, he centers this range of knowledge on his studies of the developing heart.
While an undergraduate, Bruneau was first drawn to developmental biology when he had the opportunity to work with axolotls, amphibians with the ability to regenerate limbs. A subsequent project on plant genetics stimulated his interest in genes, and Bruneau went on to explore heart gene expression and earn his PhD in physiology at the University of Ottawa. His focus on the organ has additionally been driven by the fact that heart disease impacts his own family.
Bruneau completed a postdoctoral fellowship in the Department of Genetics at Harvard University Medical School, where he worked in the joint lab of Jonathan and Christine Seidman, each highly regarded for their studies of the genetic mechanisms of heart disease. He distinguished himself within their lab by making landmark discoveries involving transcriptional dysregulation in disease. Over the years, mentorship has also been provided by Janet Rossant, a global leader in developmental biology, and Eric Olson, a molecular biologist whose research into heart formation and failure has garnered numerous awards.
From 2001 to 2006, Bruneau led a cardiovascular research and developmental biology lab at The Hospital for Sick Children in Toronto and was an assistant professor in the Department of Molecular and Medical Genetics at the University of Toronto. He joined Gladstone Institutes in 2006.
Bruneau serves as an editor for the journal Development and also participates on the editorial board of Genes & Development. In 2016, he helped found Tenaya Therapeutics, a biotechnology company combining gene therapy, cellular regeneration, and precision medicine to address the underlying drivers of heart disease.
Job Titles:
- Chief of Staff
- Member of the Scientific Leadership Team
Bethany Taylor is the chief of staff in the office of the president at Gladstone. In this role, she serves as an advisor to the president and helps execute strategic and operational initiatives. Bethany has more than 20 years of experience as an administrator at Gladstone and helps train and mentor our team of administrative assistants. She received her BA in English from Kalamazoo College and her MPA with a concentration in nonprofit administration from San Francisco State University.
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- Director, Gladstone - UCSF Institute of Genomic Immunology
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- Senior Investigator
- Senior Investigator at Gladstone Institute
Bruce Conklin's team aims to cure genetic diseases using state-of-the-art genome-engineering technology. This involves using patient-specific induced pluripotent stem (iPS) cells to derive tissue from patients who carry disease mutations that could benefit from therapeutic genome editing with CRISPR. Conklin's team focuses on modeling diseases in iPS cells, then testing the effect of genome editing. Their proof-of-concept studies are aimed at rare mutations with the highest chance of a measurable clinical impact, with the goal to expand to more common diseases. Conklin's group hopes to produce therapies that are safe and cost-effective so they can benefit the maximum number of people.
Bruce R. Conklin, MD, is a senior investigator at Gladstone Institutes. He is also a professor in the Departments of Medicine, Cellular and Molecular Pharmacology, and Ophthalmology at UC San Francisco, as well as the deputy director of the Innovative Genomics Institute.
Conklin earned a bachelor's degree in public health from UC Berkeley and completed his medical training at the Case Western Reserve University School of Medicine. During medical school, he spent 2 years as a Howard Hughes Medical Institute Research Scholar in the lab of Nobel laureate Julius Axelrod, PhD, at the National Institute of Mental Health. Conklin completed his residency in internal medicine at Johns Hopkins Hospital, and did his postdoctoral training in molecular pharmacology with Henry Bourne, MD, at UC San Francisco.
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- Member of the Lab
- Visiting Researcher
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- Member of the Core Advisory Board
- Professor of Medicine
Tcheandjieu is one of 10 scholars nationwide selected as an emerging leader who's shaping the future of health and medicine. September 4, 2024
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- Member of the Lab
- Research Technologist III
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- Member of the Core Advisory Board
- Member of the National Academy of Sciences
Charles Rice co-discovered the hepatitis C virus (HCV), for which he shared the 2020 Nobel Prize in Physiology or Medicine. He also produced the first infectious molecular clone of the virus, and established cell culture systems and animal models for studying HCV replication and evaluating antivirals.
Rice is an elected member of the National Academy of Sciences and the National Academy of Medicine and is a fellow of the American Association for the Advancement of Science. He is a past president of the American Society for Virology.
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- Member of the Board
- Media Consultant
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- Member of the Board Officers Team
- Secretary
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- Assistant
- Assistant Investigator
- Investigator
Christina Theodoris is interested in determining the circuitry of gene regulatory networks disrupted in cardiovascular disease. With a strong foundation in pediatric cardiovascular genetics, her group moves from bedside to bench by using experimental models to understand the transcriptional and epigenetic mechanisms underlying disease. Leveraging cutting-edge experimental genomics and computational modeling, they map the gene networks that drive disease progression to identify central regulatory nodes that, when targeted, have a broad restorative effect on the network. They then use machine learning approaches to identify novel network-correcting therapeutics that target these central nodes to treat the core disease mechanism rather than merely manage symptoms. This approach has already led to the identification of a candidate therapeutic for cardiac valve disease that is under further development toward clinical trials, bringing discoveries back from the bench to the bedside.
The Theodoris Lab is also focused on developing novel machine learning methodologies to fully take advantage of large-scale biological data and new biological measurements made possible by recent advances in biotechnology. They design innovative modeling approaches to enable predictions in network biology, especially in settings where discoveries are impeded by limited data, including rare diseases and diseases affecting clinically inaccessible tissues.
Gladstone Assistant Investigator Christina Theodoris salutes the biggest-ever AI biology model as a significant step towards understanding how DNA regulates gene expression.
Assistant Investigator Christina Theodoris explains how she and her collaborators used artificial intelligence to uncover how genes work together to control cells and tissues, even in situations such…
Christina Theodoris joins Gladstone as an assistant investigator to find new therapies for people with life-threatening cardiovascular diseases
Christina Theodoris is an assistant investigator at Gladstone Institutes, and an assistant professor in the Department of Pediatrics at UC San Francisco (UCSF). She completed her bachelor's degree in biology at California Institute of Technology, where she worked in the Eric Davidson Lab studying gene regulatory networks in early sea urchin development. She then completed her MD and PhD in developmental and stem cell biology at UCSF. During her graduate work in Deepak Srivastava's lab at Gladstone, co-mentored by Katherine Pollard and Benoit Bruneau, she developed an innovative network-based approach to therapeutic design leveraging machine learning and iPS cell disease modeling, which ultimately identified a candidate molecule for the treatment and prevention of cardiac valve disease currently under further development toward clinical trials.
As a postdoctoral fellow in the Department of Data Science at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard, co-mentored by X. Shirley Liu and Patrick Ellinor, she developed a novel deep learning model leveraging large-scale single cell transcriptomic data to enable context-specific predictions in settings with limited data in network biology through transfer learning. She also co-developed a machine learning methodology that systematically contrasts single-cell multimodal transcriptomic and chromatin accessibility data to infer the regulatory circuitry driving fate decisions within cell state trajectories. She completed her medical subspecialty training in pediatrics and medical genetics at Boston Children's Hospital, and her clinical experiences in pediatric cardiovascular genetics inform and direct her research program.
Job Titles:
- Director
- Member of the Scientific Leadership Team
- Director, Financial Planning and Analysis, Controller
Christopher Liong serves as the director of financial planning and analysis, as well as the controller at Gladstone. In this role, Christopher plays a crucial part in crafting financial projections and forecasts, aiding the executive team in devising optimal strategies for the future. He is a key member of the finance team who oversees policies and procedures, and ensures fiscal and regulatory compliance. Christopher holds a degree in mechanical engineering from the University of Michigan, complemented by a master of accounting from the same institution. Additionally, he is a certified public accountant and a chartered financial analyst.
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- Member of the Board
- Philanthropist
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- Member of the Lab
- Scientist
- Postdoctoral Scholar
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- Member of the Lab
- Graduate Student
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- Neuroscience Program Advisor
- Feil Family Brain and Mind Research Institute, Weill Cornell Medical College
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- Member of the Scientific Leadership Team
- Project Coordinator
Gladstone's president gave the mayor a tour of the facilities and showed him beating heart cells under the microscope.
Job Titles:
- Member of the Lab
- Research Associate I
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- Member of the Board
- Managing Director / General Catalyst
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- CEO
- Member of the Scientific Leadership Team
- President
- President of the Board
- Senior Investigator
- President of Gladstone Institute
Deepak Srivastava is president of Gladstone Institutes. He is also the Younger Family Professor and a senior investigator at the Gladstone Institute of Cardiovascular Disease, and director of the Roddenberry Stem Cell Center. At UC San Francisco, Srivastava is a professor in the Departments of Pediatrics and Biochemistry and Biophysics, and is the Wilma and Adeline Pirag Distinguished Professor in pediatric developmental cardiology.
Before joining Gladstone in 2005, Srivastava was a professor in the Department of Pediatrics and Molecular Biology at the University of Texas Southwestern Medical Center in Dallas. He is a member of the American Society for Clinical Investigation, the American Academy of Arts and Sciences, the American Association for the Advancement of Science, and the National Academy of Medicine. Srivastava served as president of the International Society for Stem Cell Research for 2019-2020 and is on the editorial board of the journal Cell Stem Cell. In addition, Srivastava has co-founded two biotechnology companies, iPierian Inc. and Tenaya Therapeutics, and chaired their scientific advisory boards.
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- Member of the Board
- Senior Vice President of Technology Strategy / ICONIQ Capital
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- Member of the Board
- Retired General Counsel
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- Member of the Core Advisory Board
- Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience / Massachusetts Institute of Technology
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- Member of the Core Advisory Board
- Anesthesiologist at Massachusetts General Hospital
- Edward Hood Taplin Professor of Medical Engineering and Computational Neuroscience / Massachusetts Institute of Technology
Emery Brown is an anesthesiologist at Massachusetts General Hospital and a statistician at MIT. His experimental research has made important contributions towards understanding how anesthetics act in the brain to create the states of general anesthesia. His work in statistics has generated algorithms that solve important challenges in the analysis of neuroscience data.
Brown is a member of the National Academies of Science, Engineering, and Medicine.
Graduate Student Emily Bulger describes her work in the Bruneau Lab, her family roots in science, and the scientist she'd like to have a conversation with
Job Titles:
- Neuroscience Program Advisor
- Banner Alzheimer 's Institute
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- Member of the Core Advisory Board
Eric Olson and his trainees discovered many of the genes that control heart and muscle formation and disease. These discoveries have revealed fundamental principles of tissue formation and provided new concepts in the quest for treatments for muscle and cardiovascular diseases. Among his accomplishments, Olson has provided a new strategy for correcting Duchenne muscular dystrophy with CRISPR technology.
Olson has co-founded multiple biotechnology companies to develop therapies for heart and muscle disease, including Myogen, Miragen, Tenaya Therapeutics, and Exonics. He is also a member of the National Academy of Sciences, the National Academy of Medicine, and the American Academy of Arts and Sciences.
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- Member of the Lab
- Scientist
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- Senior Administrative Specialist
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- Member of the Board
- President and Co - Founder / Additional Ventures
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- Neuroscience Program Advisor
- Perelman School of Medicine, University of Pennsylvania
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- Member of the Board
- Founder and Managing Director / Bay City Capital
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- Member of the Lab
- Rotation Student
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- Member of the Board
- Partner / Morgenthaler Ventures
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- Member of the Core Advisory Board
- Professor of Comparative Pathology / Chair, Department of Immunology
Arlene Sharpe and her laboratory team discovered the immunoinhibitory functions of the CTLA-4 and PD-1 pathways, which have become exceptionally promising targets for cancer immunotherapy. Sharpe's research currently focuses on translating fundamental understanding of T cell costimulation into new therapies for autoimmune diseases and cancer.
Job Titles:
- Leader
- Member of the Core Advisory Board
- Dean of the Faculty of Medicine
- Member of the National Academy of Medicine
George Q. Daley is an internationally recognized leader in stem cell science and cancer biology and a long-time faculty member of Harvard Medical School. He has testified before Congress and spoken in forums worldwide on the scientific and ethical dimensions of stem cell research and its promise in treating disease.
Daley's research uses mouse and human disease models to identify mechanisms that underlie blood disorders and cancer, and aims to understand how stem cells contribute to tissue regeneration and repair. Daley's earlier work on the BCR/ABL protein in chronic myelogenous leukemia provided critical support for the development of the highly successful chemotherapeutic agent Gleevec (imatinib).
Daley is an elected member of the National Academy of Medicine.
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- Member of the Lab
- Graduate Student
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- Senior Research Associate
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- Neuroscience Program Advisor
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- Member of the Core Advisory Board
- Member of the National Academy of Sciences
Huda Zoghbi's laboratory uses genetic, cell biological, and biochemical approaches to explore the pathogenesis of polyglutamine neurodegenerative diseases and neurodevelopmental disorders. Her work has delivered new insights into other disorders, including Parkinson's, Alzheimer's and autism, and earned her the 2017 Breakthrough Prize in Life Sciences.
Zoghbi is an elected member of the National Academy of Sciences, the National Academy of Medicine, the American Association for the Advancement of Science, and the American Academy of Arts and Sciences. She is also a Howard Hughes Medical Institute Investigator.
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- Member of the Lab
- Graduate Student
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- Associate
- Associate Investigator
Isha Jain's lab is interested in how the human body senses and responds to variations in oxygen levels. A number of diseases, including mitochondrial diseases, strokes, heart attacks, and respiratory diseases, reflect an imbalance between oxygen supply and oxygen demand. Using a combination of systems biology, metabolism, and physiology, the Jain Lab aims to identify conditions that may benefit from "turning the oxygen dial." A long-term goal of the team's work is to understand the role of oxygen in aging and age-associated conditions. Using similar approaches, the lab is also investigating pathologies associated with variations in vitamin levels in the body.
Isha Jain is an associate investigator at Gladstone Institutes, as well as an assistant professor at UC San Francisco (UCSF).
Jain received her undergraduate degree in chemical and physical biology from Harvard University. There, she worked in the lab of Erin O'Shea on bacterial chromosome segregation. Subsequently, she joined the Harvard-MIT Program in health sciences and technology. She earned a PhD in computer science and systems biology and worked in the labs of Vamsi Mootha and Warren Zapol, where she made the discovery that hypoxia could serve as a therapy for mitochondrial disorders. Before joining Gladstone, Jain was a UCSF Sandler Fellow.
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- Administrative Program Manager
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- Scientific Program Leader III
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- Member of the Board
- Founder, CEO, and Managing Director / Foresite Capital Management
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- Associate
- Senior Investigator
Jeanne Paz is an associate investigator at Gladstone Institutes. She is also an associate professor of neurology in the Kavli Institute for Fundamental Neuroscience at UC San Francisco.
Before joining Gladstone, Paz completed a postdoctoral fellowship at Stanford University, where she identified seizure control points in the brain. Paz earned her undergraduate and graduate degrees from Université Pierre et Marie Curie in Paris. As a graduate student, she studied the role of basal ganglia in regulating absence epilepsy and received an award for the best neuroscience PhD thesis in France.
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- Neuroscience Program Advisor
- the Scripps Research Institute
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- Member of the Scientific Leadership Team
- Vice President, People Services
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- Leader
- Senior Investigator
- Senior Investigator at Gladstone Institute
Jennifer Doudna is a senior investigator at Gladstone Institutes. She is also the Li Ka Shing Chancellor's Chair and a professor in the Departments of Chemistry and of Molecular and Cell Biology at UC Berkeley, as well as an investigator of the Howard Hughes Medical Institute. She is the president of the Innovative Genomics Institute.
Her co-discovery of CRISPR-Cas9 genetic engineering technology, with collaborator, French scientist Emmanuelle Charpentier, has changed human and agricultural genomics research forever. This genome-editing technology enables scientists to change or remove genes quickly, with a precision only dreamed of just a few years ago. Labs worldwide have re-directed the course of their research programs to incorporate this new tool, creating a CRISPR revolution with huge implications across biology and medicine.
In addition to her scientific achievements and eminence, Doudna is also a leader in public discussion of the ethical and other implications of genome editing for human biology and societies, and advocates for thoughtful approaches to the development of policies around the use of CRISPR-Cas9.
Doudna was awarded the 2020 Nobel Prize in Chemistry, along with Charpentier, for the development of a method for genome editing, CRISPR-Cas9. She has also received many other prizes for her discoveries, including the Japan Prize (2016), the Kavli Prize (2018), and the LUI Che Woo Welfare Betterment Prize (2019). In 2015, Doudna was named by Time magazine as one of the 100 most influential people in the world.
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- Member of the Scientific Leadership Team
- Senior Director, People Services Operations
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- Associate
- Associate Investigator
Jorge Palop's lab aims to understand the neural processes underlying cognitive decline in Alzheimer's disease and neurological conditions, such as epilepsy, autism, and schizophrenia. His team focuses on a type of neuron that stabilizes neuronal networks in the brain, called inhibitory interneurons, and the role they may play in the cognitive dysfunction and abnormal patterns of neuronal network activity that accompany Alzheimer's disease. Ultimately, Palop's group aims to define the mechanisms of cognitive dysfunction at the molecular, circuit, and network level, as well as to develop novel therapeutic approaches to restore brain functions in Alzheimer's disease.
Jorge J. Palop is an associate investigator at the Gladstone Institutes. He is also an associate professor of neurology at UC San Francisco (UCSF).
Palop has received numerous competitive honors and awards, including predoctoral and postdoctoral fellowships from the Spanish Ministry of Education and Science, the Fulbright program, the Hillblom Center for the Biology of Aging, and the Memory and Aging Center at UCSF, as well as the Ramon y Cajal and the S.D. Bechtel Young Investigator Awards. He has published his findings and reviews in many prestigious scientific journals, including Cell, Nature, Science, Nature Medicine, Neuron, Nature Neuroscience, PNAS, and The Journal of Neuroscience.
He regularly serves as a scientific reviewer for many of these journals and other organizations. He is a reviewing editor of eNeuro, the open-access online journal of the Society of Neuroscience. Palop earned a PhD in neuroscience (summa cum laude) from the University of Valencia, Spain. He did his postdoctoral training at UCSF and in the laboratory of Lennart Mucke at Gladstone.
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- Member of the Core Advisory Board
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- Research
- Scientific Program Leader III / Research Investigator
Julia Kaye, PhD, uses innovative technologies to investigate questions in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), Huntington's disease, and Parkinson's disease. She is an expert in induced pluripotent stem cell (iPSC) technology, specifically using patient-derived cells to produce neurons and investigate disease mechanisms. She subjects these human neuron models to an imaging approach called robotic microscopy in order to unravel how cells from patients with neurodegenerative diseases grow, behave, and survive differently from cells from healthy patients. She also applies machine learning approaches to analyze the images acquired from robotic microscopy to develop sensitive platforms that capture disease signatures. Kaye also has extensive experience in whole genome sequence analysis, and is involved in very large studies using this approach to discover how a person's genetic makeup can modify the onset or progression of conditions including ALS, Huntington's disease, and Parkinson's disease. Her goal is to reveal genes that are critical in disease progression with the hopes of finding potential therapeutic targets.
Julia Kaye, PhD, is a research investigator at Gladstone Institutes. She initially joined Gladstone as a postdoctoral scholar in 2009 to investigate stem cell models of neurological disease in the laboratory of Steve Finkbeiner, MD, PhD. She earned her PhD in cell and developmental biology from the University of California, Davis, where her work established paradigms of translational regulation and learned memory in C. elegans.
Kaye's research has revealed important insights in the basic mechanisms of Huntington's disease and amyotrophic lateral sclerosis (ALS). She has also been involved in multiple large consortium efforts and has helped lead collaborations with industry, foundations, and NIH-funded initiatives focused on understanding disease biology and discovering therapeutic targets.
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- Member of the Scientific Leadership Team
- Senior Director, Sponsored Programs and Research Compliance
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- U.S. Military HIV Research Program / Read Bio
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- Senior Administrative Specialist
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- Assistant
- Assistant Investigator
Karin Pelka's lab studies the cellular interactions that shape immune responses in human tumors, focusing on how these responses are regulated. Using a combination of large-scale genomic analyses and tissue imaging approaches, Pelka has identified hubs in tumor tissues where tumor cells come into close contact with immune cells. By characterizing the cells in these hubs, and the gene networks that are turned on in these cells, she aims to uncover novel ways to harness the immune system in the fight against cancer.
Karin Pelka, PhD, is an assistant investigator at Gladstone Institutes. She is also an assistant professor in the Department of Microbiology and Immunology at UC San Francisco.
Pelka aims to understand how immunological processes are regulated in human tissues in order to leverage the immune system in the fight against diseases such as cancer. Using unbiased high-throughput and high-content technologies and deeply mechanistic studies, she intends to systematically dissect how immune and non-immune cells work together to shape immune responses.
She earned a PhD in innate immunity from the University of Bonn in Germany, where she discovered a key regulatory mechanism that controls the detection of infection- or danger-associated nucleic acids by sensors of the innate immune system. She also contributed to several studies on the role of innate immune sensors in autoimmune diseases such as lupus and in the Western Diet-mediated epigenetic reprogramming of the innate immune system.
As a postdoctoral fellow at the Broad Institute of MIT and Harvard, she shifted her interest to cancer immunology and systems biology. She led a cross-disciplinary, multi-institutional single-cell RNA sequencing and spatial profiling effort on human colorectal cancer. She discovered that these seemingly heterogeneous tumors contained several conserved and spatially organized multicellular interaction networks between malignant cells and immune cells.
She is a member of the American Association for Cancer Research and the Society for Immunotherapy of Cancer.
Job Titles:
- Senior Investigator
- Senior Investigator and Director of the Gladstone UCSF Center for Neurovascular Brain Immunology
Katerina Akassoglou, PhD, is a senior investigator and director of the Gladstone UCSF Center for Neurovascular Brain Immunology. She is also a professor of neurology at UC San Francisco.
Job Titles:
- Member of the Scientific Leadership Team
- Scientists
- Senior Investigator and Director, Gladstone Institute of Data Science and Biotechnology
- Senior Investigator and Director, Gladstone Institute of Data Science and Biotechnology / Research Administration
Gladstone scientists Katie Pollard and Ketrin Gjoni answer questions about their latest study, which appears in the journal Nature Methods.
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- Staff Research Scientist I
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- Administrative Program Manager
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- Senior Investigator
- Senior Investigator at Gladstone Institute
Ken Nakamura is a senior investigator at Gladstone Institutes, and a professor of neurology at UC San Francisco (UCSF). Nakamura earned his bachelor's degree in chemistry and biological sciences from Cornell University, and his MD and PhD in neurobiology from the University of Chicago, Pritzker School of Medicine. His thesis work in the laboratory of Un Kang focused on the role of oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson's disease. Nakamura then completed an internship in internal medicine and neurology residency at UCSF, and a subsequent clinical fellowship in movement disorders at UCSF, where he continues to treat patients. He also completed a postdoctoral fellowship with Robert Edwards at UCSF, investigating the role of a small protein named alpha-synuclein in the development of Parkinson's disease. Nakamura's long-term goal is to understand how and why neurodegenerative diseases lead to the death of selective neuronal populations, and to develop new therapeutic strategies to treat them.
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- Collaborator
- Graduate Student
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- Director, Gladstone Institute of Data Science and Biotechnology
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- Member of the Scientific Leadership Team
- Director of the Gladstone Institute of Neurological Disease
- Senior Investigator and Director, Gladstone Institute of Neurological Disease
Mucke, director of the Gladstone Institute of Neurological Disease, discusses what's next for Alzheimer ™s research, the role of nonprofit research in developing new therapies, and why he's ¦
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- Member of the Board
- Founder and Chairman / Himalaya Capital
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- Member of the Core Advisory Board
- Co - Director of the Alana Down Syndrome Center
- Director, the Picower Institute for Learning and Memory at MIT
Li-Huei Tsai's laboratory takes a multidisciplinary approach to elucidate the molecular, cellular, and circuit basis of neurological disorders-especially Alzheimer's-that impact learning and memory. She and her team have created numerous applications of iPS cells for in vitro modeling of neurological diseases.
At MIT, Tsai is co-director of the Alana Down Syndrome Center and co-founder of the Aging Brain Initiative. She was previously a faculty member in the Department of Pathology at Harvard Medical School and a Howard Hughes Medical Institute Investigator. Tsai is a member of the National Academy of Medicine, the National Academy of Inventors, and the American Association for the Advancement of Science.
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- Staff Research Scientist II
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- Scientific Program Leader III / Research Investigator
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- Member of the Scientific Leadership Team
- Senior Director, Intellectual Property and Legal Affairs
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- Member of the Board
- CEO and Director / Vir Biotechnology, Inc.
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- Member of the Lab
- Student Intern
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- Member of the Core Advisory Board
- Professor in Virology
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- Member of the Lab
- Staff Research Scientist II
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- Member of the Scientific Leadership Team
- Senior Investigator and Director, Gladstone Institute of Virology
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- Member of the Board Officers Team
- Member of the Scientific Leadership Team
- Treasurer
- Vice President, Finance
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- Senior Administrative Specialist
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- Trustee in 2017, Serving First on the Gladstone Foundation Board
Nicholas J. Simon became a Gladstone trustee in 2017, serving first on the Gladstone Foundation Board.
Simon was senior managing director at Blackstone LLC from 2018-2024. He joined Blackstone as part of its acquisition of Clarus, a life sciences investment firm. Prior to joining Blackstone, Simon was co-founder and managing director of Clarus since the firm's inception in 2005.
Simon has over 40 years of operating and investment experience in the healthcare sector and has led investments in biotechnology, pharmaceutical company partnerships, and medical technology. Before Clarus, he was a general partner at MPM Capital, a healthcare venture capital firm. From 1989 to 2000, he was at Genentech, where he was Global Head of business and corporate development. Simon has served on over 30 private and public companies and is currently serving on the board of directors of Autolus Therapeutics, SFJ Pharmaceuticals and Uniquity Bio, Inc. He is also on the board of visitors of MD Anderson Cancer Center and former trustee of the California Academy of Sciences.
Simon received a BS degree in microbiology from the University of Maryland and an MBA from Loyola University.
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- Member of the Core Advisory Board
- Chairman in Medicine / Professor and Chair, Department of Molecular Genetics
Joe Goldstein and his colleague, Michael S. Brown, have been recognized with many awards for their work on cholesterol, including the Lasker Award in Basic Medical Research (1985), Nobel Prize in Physiology or Medicine (1985), and National Medal of Science (1988). Their discovery of the low-density lipoprotein (LDL) helped lay the groundwork for the development of statins, drugs that lower cholesterol in the blood and prevent heart attacks.
Goldstein is currently chair of the Albert Lasker Medical Research Awards Jury and is a member of the Boards of Trustees of the Howard Hughes Medical Institute and The Rockefeller University. He is also a member of the National Academy of Sciences, National Academy of Medicine, and a Foreign Member of the Royal Society.
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- Immunology Program Advisor
- Fred Hutchinson Cancer Research Center
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- Member of the Lab
- Research Scientist
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- Member of the Board
- President Emeritus
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- Research Associate in Alex Marson 's Lab, Discusses Her Early Exposure to Biotechnology, Her Research on HIV, and Advice She Has for Women Aspiring to Pursue Science
Rama Dajani, a research associate in Alex Marson's lab, discusses her early exposure to biotechnology, her research on HIV, and advice she has for women aspiring to pursue science.
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- President Emeritus
- Senior Investigator
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- Chief Operating Officer
- Member of the Scientific Leadership Team
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- CEO
- Member of the Board Officers Team
- Member of the Scientific Leadership Team
- Vice President, Philanthropy
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- Administrator
- Senior Executive
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- Director
- Member of the Board
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- Member of the Scientific Leadership Team
- Chief Information Officer and Vice President, Research Infrastructure
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- Principal Staff Research Scientist
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- Senior Staff Research Scientist
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- Attorney
- Member of the Board
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- Member of the Lab
- Research Associate II
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- Scientific Program and Strategy Manager
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- Member of the Scientific Leadership Team
- Senior Investigator and Director, Gladstone Center for Systems and Therapeutics
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- Member of the Board
- Consultant, Executive Management / Alexandria Real Estate Equities, Inc.
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- Senior Administrative Specialist
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- Immunology Program Advisor
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- Staff Research Scientist I
Senior Investigator Todd McDevitt, PHD, comments on the damage SARS-CoV-2 can inflict on heart cells, which he and Senior Investigator Bruce Conklin, MD, recently reported in an article deposited on…
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- Member of the Board
- Retired CFO
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- Member of the Lab
- Visiting Researcher
Bioinformatics fellow Tselmen Daria describes her work in the Tcheandjieu Lab, how her mother inspired her career, and why she chose to be a mentor this summer
Job Titles:
- Staff Research Scientist III
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- Member of the Scientific Leadership Team
- Senior Director, Facilities
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- Chief Investment Officer
- Member of the Scientific Leadership Team
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- Clinical Fellow
- Member of the Lab
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- Member of the Scientific Leadership Team
- Research Integrity Advisor Chair, Conflict of Interest Committee
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- Member of the Core Advisory Board
- Professor of Anesthesia
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- Edwards Partner
- Managing Director
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- Chairman
- Chairman in Cardiovascular Research
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- Trustee in 2016, Serving First on the Gladstone Foundation Board
Price is the founder and chief executive officer at Classic Wines, LLC. He began his career as a lawyer, becoming a partner at Bain & Company before co-founding Texas Pacific Group (TPG) in 1992. TPG invested in companies as large and diverse as J.Crew, Burger King, Continental Airlines, and Petco.
Price left TPG in 2007 to pursue his passion for the wine business. He is the proprietor of Classic Wines, LLC, and Price Family Vineyards, LLC. He owns and manages several Sonoma Coast vineyards, including Durell, William James Vineyard, Alana Vineyard, One Sky Vineyard, Gap's Crown Vineyard, and Walala Vineyard. Classic Wines has ownership interests in four additional wineries: Kistler Vineyards, Three Sticks, Head High, and Gary Farrell. An active philanthropist, Price is a board member of Common Sense Media (which rates, advocates, and educates families and schools on media and technology for kids) and Punahou School.
He completed his undergraduate studies at Stanford University then earned a JD from the Boalt Hall School of Law at UC Berkeley. He is a member of the California Bar.
Job Titles:
- Staff Research Scientist I
Job Titles:
- Administrator
- Senior Executive