INSULYSIN

Our objective is to produce well designed chemical probes to explore the role of this enzyme to untangle its role, taking into account the peculiar structure of this protein... Insulin-Degrading Enzyme known for long, remains poorly understood. It is involved in the clearance of physiologically important peptides and found in both intracellular and extracellular compartments. IDE was named on the basis of its affinity for, and ability to degrade insulin. IDE is thus suspected to be involved in the physiopathology of diabetes. Indeed it mediates the degradation of insulin ...