KOSHYLAB

With this tool in hand (the Toxoplasma-Cre system), the Koshy lab was born. We moved to the University of Arizona in 2012, where we continue to have two goals: performing great science that will improve human health and having fun along the way... While studies have been done on immune cells (who, how, why) that enter the CNS during neuro-inflammation, it has only recently been recognized that the cells of the CNS likely have a function in modulating the inflammatory response that occurs in the CNS. There are a variety of cells in the CNS but we focus on the major parenchymal cells of the CNS: neurons, which are the cells in which Toxoplasma resides in the chronic state; astrocytes, which are cells that have essential functions in synapse pruning, development of coordinated neuronal networks, neurotransmitter recycling, and innate immunity of the CNS; and microglia, which are the resident macrophage of the CNS. How Toxoplasma interacts and manipulates these cells is the focus of our..

Primary location: Tucson United States