ZDZ LAB

Centenarians are a population enriched with AD resilience, as many maintain normal cognition throughout their lifespan or significantly delay the onset of cognitive decline, despite chronological age being the major risk factor for dementia. In this comprehensive, cross-disciplinary study, we aim at building predictive molecular models of cognitive resilience based on genetic and high-dimensional molecular data collected in centenarians... People's genomes differ at tens of millions of sites, and interpreting how this variation affects phenotypes and disease risk is extremely challenging. Most disease-associated variants lie outside of protein-coding regions. We are developing highly innovative computational approaches to determine which non-coding variants contribute to differences in organismal phenotypes and disease risk... Zhengdong Zhang's laboratory at Albert Einstein College of Medicine

Primary location: Van Etten United States