SEUNG LAB

In ongoing collaborations, we are applying and refining connectomic technologies to reconstruct more fly connectomes (Mala Murthy), as well as a patch of mouse retina (Thomas Euler). We are reconstructing mouse neural circuits for memory (David Tank), decision making (Adrian Wanner and Jeff Lichtman), and reinforcement learning (Ilana Witten). These collaborations make use of the high throughput EM facility at the Princeton Neuroscience Institute. In many of the projects, neural circuit reconstruction is preceded by calcium imaging of neural activity in vivo... Today's connectomic technologies are sufficient for reconstructing an entire fly brain, and are also being applied to millimeter-scale chunks of mammalian brains. A mouse brain is 1000× larger, and a human brain 1000× larger still. There is plenty of room at the top. We are participating in a "transformative project" of the NIH BRAIN Initiative that aims to scale up connectomics to a whole mouse brain. The Princeton..