IRVINE LAB

Engineering approaches grounded in immunology hold the key to the discovery and development of novel treatments for cancer, infectious disease, and autoimmunity. To this end, the overarching goal of our laboratory is to engineer immunity through a fusion of immunology with biotechnology and materials chemistry, employing a materials science-centric approach to create new therapies based on the controlled modulation of the immune system... Licensed to kill. This image shows killing in action. The B16F10 tumor cell (green, CFSE) on the left attacked by multiple T cells (blue, DAPI) carrying nanopartilces (yellow, DiD) shows morphological alterations such as rounding, characteristic of poor cell health, while the tumor cell on right with T cell conjugates just being formed, is healthy. Entry is 100X. Image by Sudha Kumari/Yiran Zheng... Lethal encounter.The image indicates robustness of immunosurveillance, where fewer T cells are able to find the tumor cells and form conjugates- the..

Also known as: The Irvine Lab

Primary location: Cambridge United States