ROMAIN BRETTE

The activated cerebral cortex displays "high-conductance states" characterized intracellularly by intense subthreshold fluctuations, which are due to the high-level of activity in the local surrounding network. Present intracellular methods to characterize this activity are limited in resolution due to the bias introduced by recording electrodes. We address these limitations by proposing a new recording paradigm based on a computer-controlled feedback with the cell. Developing and implementing this paradigm requires a tight association between mathematics, computer science, computational neuroscience and intracellular electrophysiology (in vivo and in vitro). We aim at both the conception of novel methodologies, their testing in real neurons (essentially in vitro), as well as applying these methods to intracellular recordings in primary visual cortex in vivo... The expected contributions of this project are (a) to provide technical advances in the precision and resolution of several..

Primary location: Paris France