COURSES ON THE BBB IN CNS DRUG DEVELOPMENT

The course addresses the latest insights on the mechanisms of Blood-Brain Barrier (BBB) transport and intra-brain distribution for (CNS) drug development. It provides in-depth insight in the complex function of the BBB with regard to transport kinetics in health and disease. Also, it addresses CNS drug delivery, CNS diseases, and preclinical- clinical translation and predictions. It integrates lectures with several extensive hands-on exercises in order to deepen the knowledge conveyed... There is still a high unmet medical need in the treatment of CNS diseases and this problem is getting worse as the number of people suffering from CNS diseases is growing. This implies that there is a huge market for new CNS drugs. However, the development of new CNS drugs is notoriously difficult. For a proper CNS effect, the drug should have the ability to cross the BBB and then to reach the relevant target site within the CNS by adequate intra-brain distribution. In addition, drugs that are aimed..