JACOBS LAB

Our lab currently investigates how this extra layer of retrotransposon-mediated gene control has re-shaped gene regulatory networks involved in human brain development. Our research aims to pinpoint how specific classes of transposable elements have contributed to the evolution of human neuronal gene expression networks and understand how these changes may relate to human's increased susceptibility to neurodevelopmental disorders such as Autism and Schizophrenia and human neurodegenerative diseases such as Alzheimer's and Parkinson's disease.