MEIOSIS

Since 2000, the Cohen Lab has studied meiotic recombination and the events of prophase I in mammals, and has been funded by NIH throughout this time. Our studies focus on the class I and class II crossover pathways, and their regulatory control/interactions... Our studies focus on the DNA mismatch repair pathway, the MUS81-EME1 structure specific nuclease, and the Fanconi Anemia pathway. We study these pathways in the context of meiotic recombination as well as in the context of genome stability in the mammalian germ line... Studies in the lab are focused on identifying intervention points through spermatogenesis that could be targets of contraceptive drug targeting. Our goal is to provide cheap, safe, and reliable contraceptive options for men. These studies are funded by The Bill and Melinda Gates Foundation.

Primary location: Ithaca United States