Multi-morbidity will become the number one threat to population health and economic sustainability of health care systems. New models of care for multi-morbid persons are urgently needed. SELFIE aims to improve person-centered care for persons with multi-morbidity by proposing evidence-based, economically sustainable, integrated chronic care models that stimulate cooperation across health and social care sectors. It also aims to propose appropriate financing/payment schemes that support the implementation of these models.