CARROT

CARROT (ClAssification of Relationships with ROTations) is our novel framework for relationship inference that leverages linkage information to differentiate between rotated relationships, that is, between relationships with the same number of common ancestors and the same number of meioses separating the individuals under consideration... Accurate inference of genealogical relationships between pairs of individuals is paramount in association studies, forensics and evolutionary analyses of wildlife populations. Current methods for relationship inference consider only a small set of close relationships and have limited to no power to distinguish between relationships with the same number of meioses separating the individuals under consideration (e.g. aunt-niece vs niece-aunt or first cousins vs great aunt-niece). In association studies, these limitations can lead to unnecessary exclusions of putative relatives.