DYLAN TISDALL

The RMMR group develops new magnetic resonance imaging methods to expand the range of questions that MRI can answer. We work to make MRI more useful in challenging populations (e.g., subjects who can't stay still), expanding fast, accurate neuroimaging to the very young, old, and ill. We also work to make MRI more sensitive to lifespan changes and disease processes, helping better understand them in the lab and in life... We are developing novel MRI methods, both in vivo and ex vivo to study neurodegenerative diseases. Ex vivo MRI offers a bridge between in vivo imaging and histopathology. While histopathology allows us to observe the microscopic changes in tissue structure or cellular composition caused by disease, the spatial scale of these mthods is quite limited. Ex vivo MRI offers an opportunity to search out mesocopic changes in tissue at the scale of whole hemispheres or even whole brains. We work closely with the Penn Frontotemporal Dementia Center and the Penn Alzheimer's..