SYSIMIT

The overarching goal of the SYSIMIT projects is to exploit the full prognostic potential of routinely obtained biopsy samples in transplantation and hereditary breast cancer. Compared to conventional "descriptive" evaluation of biopsies, the fundamentally new approach is including the spatio-temporal dimension of dynamic immunological processes in the interpretation of microscopic image data, based on advanced image analysis and mathematical models of underlying dynamic processes... SYSIMIT realizes a systems medicine approach by integrating image mining approaches adopted from satellite-based remote-sensing image analysis technologies, three-dimensional simulations of cell-cell interactions, and comprehensive integrative analysis of multimodal biomedical data such as genome-wide molecular data and autoantibody profiles, in a consequently interdisciplinary effort.