SEMATHERA

SemaThera was founded in Montreal, Quebec, where the company's research and development facilities are located. In addition, it has operations in Boston, MA... Semaphorin 3A (SEMA3A) has been shown to increase vascular permeability, promote retinal inflammation as well as cellular senescence and inhibit retinal vascular regeneration in rodent models. SemaThera has developed a family of biological traps that are designed to bind and sequester SEMA3A and other cytokines associated with diabetic retinopathy. Studies using several orthologous models of retinal vascular diseases have shown that our biological traps bind and neutralize SEMA3A in vivo and consequently reduce the amount of avascular areas by facilitating desirable physiological re-vascularization, reducing retinal vascular leakage and reducing inflammation.

Also known as: SemaThera Inc.

Primary location: Montreal Canada