AGECURVE

Current aging clocks used to assess healthy longevity interventions do not measure somatic mutation burden, which informs of the foundational aging hallmark genome instability. Not measuring existing somatic mutation burden before an intervention, the current default practice, can potentially offset biological age assessment by decades, and not assessing the potential changes in that burden due to and after the intervention can miss important additional mechanisms, effects and opportunities. We believe that Cell Tree Rings can serve as a core component for combined aging clocks to mitigate current uncertainty in the assessment of geroprotective trials.

Primary location: United Kingdom