VICC

The Variant Interpretation for Cancer Consortium (VICC) is a Driver Project of the Global Alliance for Genomics and Health. Our mission is to standardize the curation, representation, and interpretation of clinically-relevant evidence associated with genomic variation in cancers... Terminology. We provide definitions for gene fusions and disambiguate several classes, including chimeric product and regulatory fusions, from related but distinct concepts such as genomic rearrangements. We also elaborate on the distinction between gene fusions represented as aggregated concepts in cohort studies and biomedical knowledgebases from individual fusions observed in a sample.