RAINES LAB

We are developing powerful chemical methods to synthesize and modify proteins. In 2000, we invented the "traceless Staudinger ligation" to couple a peptide with a C-terminal phosphinothioester to one having an N-terminal azido group to form an amide bond. (An optimal reagent for mediating this ligation is…... By understanding the underlying cellular processes, we are able to endow an otherwise innocuous human enzyme with clinically useful cytotoxicity. Ribonucleases catalyze the cleavage of RNA. Early-on, we made contributions to…... By exploiting the fundamental basis for the stability of collagen (which is the most abundant protein in humans), we are creating new materials to detect and treat wounds, tumors, and other abnormalities. For 25 years, the prevailing paradigm had been…

Primary location: Cambridge United States