THE CURE STARTS NOW FOUNDATION

CONNECT's goal is to fill this critical gap by conducting nimble, scientifically-rational, international trials to demonstrate the safety and feasibility of incorporating novel agents into the most effective current regimens for children with newly-diagnosed high-risk brain tumors... In this research study, we want to learn about the safety of the study drugs, ribociclib and everolimus, when given together at different doses after radiation therapy. We also want to learn about the effects, if any, these drugs have on children and young adults with brain tumors... CONNECT is an international collaborative network of pediatric cancer centers with the objective to improve outcomes for children with newly-diagnosed, high-risk brain tumors (including diffuse intrinsic pontine glioma, high-grade gliomas, atypical teratoid rhabdoid tumors, and high-risk medulloblastoma). We conduct small, scientifically-rational, pilot studies to assess feasibility and early efficacy of incorporating..

Also known as: Connect Consortium