DYLAN OWEN LAB

We are a biophysics group covering three levels of research: Microscopy method development, membrane biophysics and immunology... We work to develop new fluorescence microscopy tools designed to study the plasma membrane and related biophysical phenomena. In particular, we develop post-processing analytics for single-molecule localisation microscopy (SMLM) data, whose output is in the form of a spatial point pattern, rather than a traditional pixelated image. In particular, we have developed a variety of cluster analysis methods for the quantitative description of molecular spatial organisation. This includes nanoscale clustering in 2D and 3D, live-cell cluster analysis and multi-colour co-cluster analysis. We have also developed algorithms to extract descriptions of fibrous patterns, such as those derived from components of the cytoskeleton. Finally, we also employ environmentally-sensitive fluorescent probes which report on their local biophysical and biochemical environments. These..

Primary location: London United Kingdom