IQR

All genotyped mice in the colony were included in the analysis (= 251). APP, as a result of the selective decrease in kinesin light chain 1 expression. Our findings suggest that A trimers might cause axonal transport deficits in AD. (Decker et al., 2010; Vossel et al., 2010; Vossel et al., 2015). In addition to A, tau is known to be concentrated preferentially in axons, where it stabilizes microtubules that serve as tracks for the transport of organelles, vesicles, and proteins (Hirokawa XCL1 and Takemura, 2005) and has been proposed to induce neuronal cell death by interfering with microtubule-dependent axonal transport (Stamer et al., 2002). Despite convincing observations showing that tau alters axonal transport (Ebneth et al., 1998; Dixit et al., 2008), it is less clear whether tau acts similarly (Yuan et al., 2008). Recent studies indicated that, although tau did not appear to affect axonal transport under baseline conditions, tau protein levels were critical for axonal transport..

Primary location: Carter Et United States