CENTER FOR THE GENETICS OF HOST DEFENSE UTSW

Concurrent with obtaining a parts list, we work to determine the job of each part, and how the parts fit together to control characteristics of human biology, for example, blood glucose levels or susceptibility to a particular disease (Figure 2). We use a wide variety of methods in molecular biology, biochemistry, biophysics, structural biology, bioinformatics, and other disciplines to test hypotheses concerning the genes in question. As we continue to discover more genes necessary for a particular process, we gain insight into the mechanics of that process and can begin to understand the roles of individual genes. We publish our findings in top-tier peer-reviewed journals. We also directly post mutations, in both known and novel genes, to the Mutagenetix database... Our Technical Approach to forward genetic analysis involves exome sequencing of the G1 male progenitor of each pedigree carrying ENU-induced mutations. On average, 97% of all coding and critical splice junction..

Primary location: Dallas United States