VALBIOTIS - Key Persons

Job Titles:

• Executive Director, Crédit Mutuel Equity SCR. Member of the Supervisory Board and Audit Committee

A graduate of ICN Business School in Nancy, with a post-graduate degree in accounting (DECS), and a member of the French Society of Financial Analysts (SFAF), Agnès began her career in 1986 at the Banque de Vizille, specialized in mid-cap transactions, which merged in 2011 with other entities of the Crédit Mutuel Alliance Fédérale group to create CM-CIC INVESTISSEMENT. From 1990 to 1997, she served as Financial Director and Board Member of the SHB hotel group in Lyon, which went on to merge with ACCOR. In 1997, she joined AVENIR TELECOM, a distributor specialized in mobile telephony, for whom she led the initial public offering on Eurolist C in November 1998. For 17 years, as the Administrative and Financial Director of the group (1,800 employees and 290 million in revenue in 2015), she managed a number of mergers and acquisitions and also oversaw investor relations. In 2015, she was appointed Financial Director of the transport and logistics group TRANSALLIANCE (3,000 employees and 600 million in revenue), which operates in seven European countries. From June 2016 to February 2018, she was the Administrative and Financial Director at IDEOL, an innovative company created in 2010 in La Ciotat (46 employees, 4 million in revenue) and a leader in floating offshore wind power.

Job Titles:

• CFO

Frédéric PELONG CFO. Member of the Executive Committee Frédéric brings a wealth of experience in finance, acquired over more than twenty years working for mid-caps and major international groups managing high-profile brands. Former Financial Audit Manager at E&Y, Frédéric then held various cross-functional financial positions at Pernod Ricard before becoming Chief Financial Officer of the Swiss subsidiary. He was subsequently appointed Chief Financial Officer of the Christofle Group, and more recently Audika. Over his career, he has acquired a solid expertise in supporting growth and development in new markets, mastering a wide variety of business models. Frédéric is a graduate of Kedge and holds a DECF accounting and financial diploma.

Job Titles:

• Medical Affairs and Clinical Development Consultant. Member of the Supervisory Board and Audit Committee

Jean has over 30 years' experience in various international executive positions and cutting-edge expertise in the pharmaceutical and nutrition sectors, their environments and their challenges. The Scientific Director of NOVARTIS Pharma SAS, and then Special Scientific Adviser to the CEO and a member of the Executive Committee, Jean was also Chief Medical Officer and a member of the Executive Committee of Nestlé Health Science in Vevey, Switzerland, for two years, contributing to the growth of the personalized medicine and health nutrition business segments. For close to 20 years, Jean also held various executive and R&D positions at SANOFI, including that of Vice-President and Head of Market Access, Vice-President and Head of Global Regulatory Affairs, and Vice-President and Deputy Head of Global Medical Affairs. Jean is also Vice-President of ARIIS (alliance for research and innovation in health industries) and Chairman of the working group on the attractiveness of France for clinical research headed by Leem, an association of French pharmaceutical companies. Before joining the pharmaceutical industry, Dr. Zetlaoui was a hospital practitioner at the Bicêtre University Hospital (CHU). Jean has a PhD in Medicine and is specialized in anesthesia and resuscitation. He also completed an Executive MBA in Finance and International Business at the ESSEC Business School (1991).

Job Titles:

• CEO
• Founder
• Chairman of the Supervisory Board and Member of the Compensation Committee

Laurent has a PhD in Physics and Chemistry, with a specialization in nanomaterials, from the Pierre and Marie Curie University and the CEA (French Commission for Atomic Energy), and a Master of Advanced Studies in Condensed Matter Physics from UPVI-ESPCI (Paris). He has acquired extensive experience in the science and techniques associated with nanomedicine, a field in which he has worked for over a decade. His research is at the forefront of chemistry, biology and physics, and has enabled him to design a certain number of practical applications in nanomedicine, such as the NanoXray technology, which could herald the start of a new era in cancer treatment. Before founding Nanobiotix in 2003, for several years, Laurent worked as a consultant in the development of nanotechnology applications for groups such as Sanofi (pharma), Guerbet (medical imaging) and Rhodia (chemistry), as well as for biotech start-ups. The author of 35 international scientific publications and papers, Laurent has filed many patents and topped off his career with a post-doctorate at the Institute for Lasers, Photonics and Biophotonics of SUNY (State University of New York), Buffalo, in the United States.

Job Titles:

• CMO

Murielle CAZAUBIEL CMO. Member of the Executive Committee After managing a team responsible for the implementation and development of clinical study management at Nantes University Hospital, in 2002, Murielle founded BIOFORTIS, a leading CRO (contract research organization). In addition to achieving the growth of her company, Murielle contributed to local economic development by attracting the MÉRIEUX pharmaceutical group to Nantes. In 2009, BIOFORTIS joined the MÉRIEUX group, and Murielle successfully managed its integration into the MÉRIEUX NUTRISCIENCES subsidiary. In addition, Murielle took on the role of Chair of the "Atlanpole Biothérapies" cluster from 2012 to 2018 with a view to establishing new therapies and accelerating the development of personalized medicine by facilitating joint university and industry research programs.

Job Titles:

• CSO - PhD, HDR. Member of the Executive Committee

With over 15 years of research experience, Pascal has exceptional expertise in metabolic diseases. Pascal was a Lecturer at the University of Clermont Auvergne between 2008 and 2018, and has headed the institution's technical functional assessment platform since 2010. He has also launched several international scientific partnerships with Vanderbilt University (Nashville, USA), the Maine Medical Center Research Institute (Portland, USA) and the University of Texas (Houston, USA) with regard to research projects on the pathophysiology of type 2 diabetes. In 2005, Pascal graduated with a PhD in Biological and Biochemical Health Sciences from Montpellier University and was also granted the French higher degree authorizing the supervision of research (HDR - Habilitation à Diriger des Recherches) in 2016. Pascal has been heavily involved in Valbiotis since it was founded in 2014. As a member of the Scientific Committee, Pascal was in charge of collaborative projects involving the University of Clermont Auvergne and Valbiotis. In 2017, he was appointed Chief Scientific Officer (CSO) at Valbiotis and took over management of the Discovery and Preclinical and Translational Research Department. As such, Pascal is also at the helm of our two R&D centers in La Rochelle and Riom. Furthermore, he is the co-inventor of a number of key technologies used for the development of Valbiotis.

Job Titles:

• COO
• Expert

Sébastien BESSY COO. Member of the Executive Committee Sébastien BESSY is an expert in the Consumer Healthcare sector, having held various marketing and innovation positions at major pharmaceutical companies over the past 20 years. He has unique international experience, both operational and strategic, in consumer marketing and product innovation, particularly in Europe, Asia including China, North America and Latin America. During his last 6 years at Ipsen, Sébastien held the positions of Vice-President Global Marketing & Portfolio Strategy Consumer Healthcare and Vice-President Global Strategic Operations Consumer Healthcare. Prior to joining Ipsen, Sébastien previously held the positions of Managing Director Europe at Biofortis, a subsidiary of Mérieux Nutrisciences, Global Director of "Probiotic Platform" Innovation at Merck Consumer Healthcare, Global Strategic Marketing Director at Merck Consumer Healthcare and Global Marketing Manager at Reckitt Benckiser. Sébastien is a graduate of ISC Paris and began his career at Sanofi Aventis.

Job Titles:

• CEO - PhD - HDR. Co - Founder

After completing a thesis on nutrition in the field of cardiovascular and metabolic diseases at the Laboratory of Applied and Fundamental Bioenergetics (U1055 INSERM) at Joseph Fourier University (Grenoble, France) under the supervision of Professor Xavier Leverve, Sébastien worked at a spin-off of the Free University of Brussels in Belgium on a drug candidate in the area of enteral and parenteral nutrition. In 2007, he joined the Lescuyer Laboratory, where he was rapidly entrusted with management of the Research & Development Department. In this position, he notably oversaw the entire application process for one of the only health claims ever to obtain a positive response from the EFSA for reducing a risk factor for cardiovascular diseases. Sébastien chaired the Biopôle Santé - Réseau Expert, Territoire d'Innovation, Service de Valorisation en Santé (regional expert network for innovation and optimization in the health sector) for the Poitou-Charentes region and later for Nouvelle-Aquitaine for over five years until March 2017. He was also granted the French higher degree authorizing the supervision of research (HDR - Habilitation à Diriger des Recherches) from Blaise Pascal University (which later became the University of Clermont Auvergne, Clermont-Ferrand), allowing him to officially supervise PhD students. Sébastien is an active member of the French Nutrition Society and the American Diabetes Association. He is also a member of the Strategic Committee of La Rochelle Technopole and President of the La Rochelle University Foundation. Sébastien has written over 35 international scientific articles and papers, and has developed more than five patent families.