MAGIN LAB

Tissues and organs depend on a strong cytoskeleton and its interaction with cell adhesion structures in order to provide strength to tissues and to maintain order at the subcellular level. Our research aims to understand the multiple functions of keratin proteins, which form the major cytoskeleton in all epithelia, during development, pathogenesis and regeneration of epithelia. We have a strong interest in the epidermis, where keratins not only maintain tissue strength and adhesion, but coordinate skin barrier formation, immune responses and organelle functions. This interest results from the fact that mutations in epidermal keratin genes cause a large number of rare but life-threatening blistering and hyperkeratotic genetic diseases, e. g. epidermolysis bullosa simplex for which currently no therapy exists... One of the aims of our work is directed toward understanding molecular mechanisms of the blistering skin disease Epidermolysis Bullosa Simplex (EBS), caused by mutations in..

VAT numbers: DE 141510383

Primary location: Leipzig Chile