The Prevention Policy Modeling Lab models the health impact, costs and cost-effectiveness of infectious disease treatment and prevention programs in the United States. We work closely with collaborators in the National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (NCHHSTP) at the Centers for Disease Control and Prevention to inform U.S. health policy and guide public health decision-making at national, state and local levels. The models we build incorporate evidence-based prevention strategies, emphasize cross-cutting initiatives and produce results that can be operationalized within healthcare and other sectors.