PROEURODILINET

Idiosyncratic drug-induced liver injury (DILI) is an acute adverse hepatic reaction that occurs in only a small proportion of individuals exposed to a drug. It is unexpected from the known pharmacological action of the agent, leading to illness, disability, hospitalization, including life threatening liver failure (10- 15%), need for liver transplantation and death. DILI manifests in a variety of clinical presentations with a 13-17% of cases remaining unresolved at 6 months, and 8% at 12-months follow-up leading to transplantation in 2-4% and in 6-8%. DILI represents a major challenge for clinicians, the pharmaceutical industry and regulatory agencies worldwide. DILI due to commonly used drugs continues to be an important clinical problem with a crude annual incidence of 19 per 100,000 individuals and 22% of the cases requiring hospitalization... Burden of DILI: The concordance between hepatotoxicity in animal and humans is poor which means that adverse hepatic reactions account for..

Primary location: To Cost United States