EJKIMLAB.COM

The mammalian cortex is composed of numerous functionally specialized areas. Interactions between these areas, mediated by widespread yet precise cell type specific circuits, are central to the neural computations that generate perception, cognition, and behavior, and make us who we are. Since circuit-level understanding of this brain-wide neural network will elucidate fundamentals of the human mind and behavior, my laboratory focuses on understanding the organizational logic of long-distance cortical circuits and the molecular mechanisms of their development using mouse visual cortex as a model. In the mature brain, what are the connectivity and functional bases of neural circuits at the cellular level? Using novel trans-synaptic tracers and in vivo imaging, we are investigating the identities of brain-wide input and output neurons and their functional contributions to information processing. In the developing brain, what are the mechanisms that match gene expression to neuronal..

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