GUTTMAN LAB - Key Persons
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- Undergraduate Student / Research
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- Graduate Student, Biochemistry & Molecular Biophysics / B.S. University of California
Allen is studying how RNA compartmentalization and genome organization evolve over time in the nucleus. By mapping RNA and DNA in both space and time, he aims to better understand the function of lncRNAs in mammalian gene regulation.
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- Senior Research Scientist / B.S. Arizona State University
Amy is investigating functional and cell biological outcomes following perturbations of RNA-protein interactions found to be important from other studies within the group. Most commonly, she uses mouse embryonic stem cells as a model system, with genomic targeting carried out by CRISPR-Cas9 strategies.
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- Graduate Student, Biology / B.S. California State University
Andrew is developing new, high-throughput, genome wide, technologies to study RNA, DNA, and nuclear proteins simultaneously. Once established, these technologies will be used to understand how RNA and DNA work with proteins to influence nuclear structure, gene expression, and cell identity.
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- Graduate Student ( Biology ) Stanford University
Ben is developing new single cell functional genomic assays to examine how nuclear structure, chromatin states, and transcription regulators coordinate gene expression in individual cells. Google Scholar | btyeh@lncrna.caltech.edu
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- Assistant Professor, Washington University School of Medicine in St. Louis
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- Assistant Professor, University of California, San Diego ( Department of Biochemistry )
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- Assitant Professor, M.D. College of Medicine at the University of Vermont
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- Clinical Laboratory Scientist, UCLA
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- Technology Development Fellow, Wyss Institute
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- Clinical Laboratory Scientist, Arrowhead Regional Medical Center
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- Assistant Professor, Stanford University ( Department of Genetics ) Research Staff
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- Graduate Student, Biology / B.a. University of California
Jimmy is studying the roles of non-coding RNAs and RNA-binding proteins (RBPs) in regulating transcription and chromatin organization. He is developing high-throughout, scalable methods to study RNA-protein interactions genome-wide.
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- Group Leader, IMBA Vienna
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- Senior Research Scientist
Mario is working to develop and implement methods that can help us understand the role of RNA-protein interactions in gene regulation.
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- Professor of Biology
- Professor, Division of Biology and Biological Engineering, Caltech / Associate Director, UCLA - Caltech Medical Scientist Training Program ( MD - PhD Program )
Mitch Guttman is a Professor of Biology in the Division of Biology and Biological Engineering at the California Institute of Technology (Caltech). He received his PhD from the Department of Biology at MIT where he worked with Eric Lander at the Broad Institute of MIT and Harvard. He established his lab as an independent Fellow at the Broad Institute of MIT and Harvard prior to joining the faculty at Caltech in June 2013. He is currently an Investigator at the Heritage Medical Research Institute and a Robertson Investigator of the New York Stem Cell Foundation. He is a recipient of numerous scientific honors and awards including the NIH Director's Early Independence Award, Pew-Steward scholar in Cancer Research, a Searle Scholar, Ben Barres Early Career Investigator at the Chan Zuckerberg Initiative, and is the recipient of the Wilson S. Stone Memorial Award from the MD Anderson Cancer Center in recognition of his "outstanding contribution to biomedical research" and a 2020 NIH Director's Transformative Research Award.
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- Graduate Student, Biochemistry and Molecular Biophysics / B.S. University of California
Noah is investigating the regulatory function and biophysical properties of phase-separated protein compartments in cell nuclei. He is developing a method to profile nucleic acid content and stoichiometry in compartments formed by proteins of interest.
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- Senior Computational Scientist, National Institutes of Health
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- Lab Technician - Assistant / B.S. University of California
Olivia is working with several members of the lab to support their work on RNA-protein interactions. She generates valuable data that furthers the group's research progress.
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- Principal Bioinformatics Engineer, Fulcrum Genomics
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- Director, Applied Biology Team Lead, Dyno Therapeutics
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- Graduate Student, Bioengineering
Paulomi is investigating nuclear changes that result from RNA-mediated toxicity in amyotrphic lateral sclerosis (ALS). She is developing a scalable, high-throughput technology that allows the multiplexed detection of proteins in complex with other proteins, DNA, and RNA in the nucleus to better understand mechanics of neurodegeneration.
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- Graduate Student, Biology / B.a. University of California
- Nuclear Compartmentalization As a Mechanism of Quantitative Control of Gene Regulation.
- Student in Division of Biology and Biological Engineering at Caltech through the UCLA - Caltech Medical Scientist Training Program
Prashant's training and experience has also involved exploring the intersection between science, policy, and the public. He was Editor-in-Chief of Berkeley Scientific Journal and a science writer for PLoS before starting medical school. In addition to science writing, he is interested in shaping policy decisions by advocating for continued federal funding of basic science research. To that end, he has participated in face-to-face discussions with advocates and politicians directly involved in policy decisions at the federal level through his involvement in science policy programs in Washington DC and the Dr. Lucy Jones Center for Science and Society. Additionally, he led the LGBTQ+ group at the Caltech Center for Inclusion and Diversity, where he organized social and outreach events to improve all facets of LGBTQ+ life.
Nuclear compartmentalization as a mechanism of quantitative control of gene regulation.
Prashant is studying how sites of RNA processing (e.g nucleoli, nuclear speckles, histone locus bodies, and Cajal bodies) are compartmentalized in 3D structures within the nucleus in the context of normal physiology and disease. He maps the spatial compartmentalization of active genes at nuclear speckles and investigates the resulting impact this has on the kinetic efficiency of RNA splicing.
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- Student, Stanford School of Medicine
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- Senior Scientist, Cell Biology, Pfizer
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- Student, Johns Hopkins University
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- Senior Scientist, Celsius Therapeutics
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- Senior Research Scientist, Casma Therapeutics