DANIELMARBACH.COM

We also work on the integration of gene expression profiles from 555 LCLs derived from CoLaus subjects using RNAseq technology. Our data show very good concordance of cis-eQTLs with those identified in previous studies. Searching for associations between gene expression and metabotype profiles revealed several gene-metabotype pairs with highly significant associations. Our current research focuses on better understanding these associations and develop tools to dissect genotype-gene-metabotype triangles to map potential pathways and chains of causality: Does a change in gene expression lead to an altered metabolite concentration or vice versa?... Our project benefits from the access to an unprecedented set of cohorts, including the UK Biobank, the Rotterdam Studies, OphtalmoLaus, BrainLaus, and SKIPOGH, augmented by data from Inselspital Studies and the CHUV's PAD registries. Together they provide multimodal imaging of retinal and non-retinal vasculature, complemented by structured..

Primary location: Lausanne Switzerland