TrentinoSalute4.0 (TS4.0) is the "Competence Center on Digital Health" approved by the Trentino Provincial Council as a policy instrument to coordinate the work on digital health in the region. TS4.0 represents the meeting point between the health system, research and the territory. It represents the instrument of cohesion between the guidelines of health planning, the innovation needs expressed by the Provincial Health Service and the opportunities offered by research and new digital technologies.