GENZYME

Based on the results, most patients with CAD in this study experienced hemolysis despite receiving pharmacotherapies... The case and control cohorts were matched by age, sex, race, region, index year, and follow-up period using 1:5 nearest neighbor matching... In cold agglutinin disease, certain abnormal bone marrow cells produce antibodies called cold agglutinins, which activate a part of the immune system known as the complement pathway. This activation results in the constant destruction of red blood cells, known as hemolysis.

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