BCL10

Different CARMA/caspase-recruitment domains (CARDs) link to B-cell lymphoma/leukemia 10 (BCL10) -mucosa-associated lymphoid tissue (MALT) 1 in response to different upstream stimuli BCL10/MALT1 complicated recruitment to distinct CARMA/CARD proteins depends on activation of different receptor types forming different CBM complexes. Although BCL10 promotes survival of thymocytes, it's dispensable for total B or T cell lineage commitment (18, 20). But more comprehensive immune phenotyping revealed that BCL10 is needed for the appropriate development of regulatory T cells, natural killer (NK), and NKT cells in addition to marginal zone (MZ) and B1 B cells (21, 22). B and T lymphocytes from BCL10-deficient mice are defective in NF-κB indicating, fail to upregulate cytokines such as IL-2, and don't proliferate in response to TCR and BCR stimulation, which result in blunted antigen reactions and acute immune deficiency (18, 22). Similar signaling defects are found in mice lacking CARD11 or..