GEUKING LAB

The Geuking Lab investigates the interactions between the intestinal microbiota and the host immune system in health and disease. The microbiota has been shown to be implicated in a range of immune-mediated disorders including inflammatory bowel disease, autoimmunity, and allergy. Therefore, altering the composition or function of the microbiota is a promising therapeutic approach to modulate immune responses involved in disease. Because T helper cells are involved in both immune adaptations to colonization and pathologic processes in disease, the lab focuses on the interaction of the microbiota with T helper cells... The team uses axenic (germ-free) and gnotobiotic (known defined microbial status) in vivo models in combination with genetically modified commensal species to interrogate whether and how the microbiota can modulate T helper cell responses. This allows for carefully controlled and defined experiments to study how the microbiota modulates T helper cell response, but also..

Also known as: Markus Geuking Lab

Primary location: Calgary