FARHANLAB

Safeguarding the cellular proteome is of fundamental importance and it is thus of no surprise that nearly 70% of cellular energy is devoted to handle the proteome. The balance between protein synthesis, folding, trafficking and degradation is referred to as proteostasis. Our group focuses on how proteostasis is regulated by signalling to and from endomembranes. In particular are we interested in the regulation of membrane traffic, organelle dynamics and autophagy. We employ a set of methods to study these processes such as live cell confocal microscopy, SRRF stream imaging, FRAP and high-content RNAi screening. We use the knowledge gained from fundamental cell biology and use to better understand human diseases or to develop new therapies. Two main areas of interest of our lab are the role of secretion in breast cancer migration and invasion as well as the role of proteostasis in multiple myeloma... Our lab has two main research areas: (i) The regulation of Proteostasis and membrane..