PERSHING SQUARE SOHN CANCER RESEARCH ALLIANCE - Key Persons

Job Titles:

• Independent Advisor
• Philanthropic Advisor and Independent Consultant

Christy Hudson (formerly Barrow) is an Independent Advisor focused on philanthropic initiatives in life science and medical research. She is currently retained by the Pershing Square Foundation, supporting its life science portfolio and programming. In particular, she is responsible for leading and managing all aspects of the Foundation's two in-house grantmaking initiatives, the MIND Prize in cognitive health and neurodegenerative disease and the Pershing Square Sohn Cancer Research Alliance (PSSCRA), which annually awards the Pershing Square Sohn Prize that emboldens early-career investigators to pursue innovative cancer research projects at a stage when traditional funding is lacking. She also currently co-chairs the Grants Administration Community of the Health Research Alliance, a collaborative member organization of nonprofit research funders that is committed to maximizing the impact of biomedical research to improve human health. Prior to launching her independent practice, Christy was previously a Program Director at The Pershing Square Foundation. Christy came to the Foundation from Shizuoka City, Japan, where she promoted international understanding and communication as a participant in the Japan Exchange and Teaching (JET) Program. Before the JET Program, Christy worked as a Development Officer at The Rockefeller University, a world-renowned center for scientific research and graduate education, assisting in fundraising, donor stewardship, and event planning for initiatives focused on empowering women scientists as well as furthering critical research on child and adolescent health. As a recent college graduate, Christy worked in the laboratory of Dr. Abigail A. Baird, Professor of Psychological Science at Vassar College, whose research focused on the brain and behavioral basis of adolescent development. Christy graduated Phi Beta Kappa from Vassar College in 2011 with a B.A. with honors in both Psychology and Japanese.

Job Titles:

• Professor of Psychological Science at Vassar College

Job Titles:

• Program Associate

Emily Hotaling is a Program Associate at The Pershing Square Foundation. She offers general support of the Foundation's communications and life science programming and assists the Program Director in the day-to-day management of the Pershing Square Sohn Cancer Research Alliance (PSSCRA), which annually awards a cancer research prize that emboldens early-career investigators to pursue innovative research projects at a stage when traditional funding is lacking. Prior to working at The Pershing Square Foundation, Emily was a Marketing Associate at Penguin Random House, where she worked on nonfiction and literary fiction titles. In this role, Emily developed and executed over 20 marketing campaigns per year, managed the content development and creation of consumer materials, and helped authors grow their platforms through brand and influencer outreach. Emily graduated from the University of Michigan with a BA in English.

Job Titles:

• Co - Founder, the Sohn Conference Foundation

Evan Sohn has been a dedicated and energetic advocate of a cure for pediatric cancer for 25 years. While building a career growing and advising businesses in the technology sector, Evan co-founded the Ira Sohn Conference Foundation in honor of his brother Ira. The Foundation raises funds through its flagship Sohn Investment Conference, held annually in New York City. Bill Ackman is a long-time supporter of the Foundation and frequently featured speaker. Proceeds from The Sohn Investment Conference benefit pediatric cancer research and care. The Foundation also partners with Sohn Conferences around the globe to raise funds for charitable causes; altogether Sohn conferences have raising over $85M. Sohn global investment conferences include Sohn Australia, Sohn Brazil, Sohn Canada, Sohn Geneva, Sohn Hong Kong, Sohn India, Sohn London, Sohn Monaco, Sohn San Francisco, and Sohn Tel Aviv, A graduate of NYU Stern School of Business, Evan is involved in a number of technology companies and on the Board of the Day School he went to as a child. Evan resides in Englewood, New Jersey with his wife Michelle and 3 children.

Job Titles:

• Assistant Member in the Molecular Biology Program at Memorial Sloan Kettering Cancer Center

John Maciejowski, PhD is an Assistant Member in the Molecular Biology Program at Memorial Sloan Kettering Cancer Center. Research in the Maciejowski lab focuses on understanding how innate immune defenses impact cancer genome integrity and anti-tumor immunity. Dr. Maciejowski started his lab in 2017 after performing postdoctoral work with Dr. Titia de Lange at Rockefeller University. While in the de Lange lab, Dr. Maciejowski discovered that fused chromosomes can survive cell division intact ultimately giving rise to clustered mutations that resembled patterns often found in cancer genomes. Dr. Maciejowski performed his doctoral studies as part of the inaugural class at the Gerstner Sloan Kettering Graduate School of Biomedical Sciences. One current focus of the Maciejowski lab is to understand the roles of the antiviral APOBEC3 deaminases in cancer genome evolution. Parallel work in the lab investigates how nuclear envelope instability at nuclear atypia like micronuclei causes DNA damage and pro-inflammatory immune responses. His lab develops and applies cell models to understand how tumor intrinsic processes provoke antiviral innate immune responses. Dr. Maciejowski is a Frank A. Howard Scholar, Pew Biomedical Scholar, and recipient of the Regeneron Prize for Creative Innovation.

Job Titles:

• Assistant Professor

Kyle K. Payne, PhD, is an Assistant Professor in the Department of Medicine at Rutgers University Robert Wood Johnson Medical School, and a resident member of the Rutgers Cancer Institute of New Jersey within the Section of Cancer Immunotherapy. Dr. Payne received a Bachelor's degree in Biology from Indiana University in 2005, and obtained his Ph.D. in Tumor Immunology from Virginia Commonwealth University in 2015 under the mentorship of Dr. Masoud H. Manjili. He then pursued his postdoctoral training at the Wistar Institute, the University of Pennsylvania, and Moffitt Cancer Center in the laboratory of Dr. Jose R. Conejo-Garcia, where he identified novel mechanisms of immune suppression mediated by checkpoint molecules in the tumor microenvironment. Since joining Rutgers Cancer Institute of New Jersey as a faculty member in 2021, Dr. Payne has turned his attention towards elucidating the intrinsic impact of stress-response signaling pathways within tumor-infiltrating immune cells. His lab currently focuses on understanding how T cell-intrinsic stress-response signaling affects lipid trafficking to regulate protective immunity in the tumor microenvironment. The goal of Dr. Payne's work is to translate the discoveries in his lab into the clinic in order to produce more effective cancer immunotherapeutics. Dr. Payne is a former American Cancer Society Postdoctoral Fellow; he recently received a V Scholar Grant from the V Foundation for Cancer Research, as well as an Early Career Investigator Grant from the Ovarian Cancer Research Alliance.

Job Titles:

• Architect
• Designer
• Trustee
• Architect, Designer and Inventor

Neri Oxman is an architect, designer, inventor, and Media Lab professor where she is the founding director of The Mediated Matter Group, an experimental design practice combining commissioned works with the creation of enabling technologies and scientific knowledge. Oxman pioneered the field of Material Ecology, which considers form generation, manufacturing, the environment and the material itself as inseparable dimensions of design. Oxman's team operates at the intersection of computational design, digital fabrication, materials science and synthetic biology; and applies that knowledge to design across scales and disciplines, from micro to building scale. Oxman's work - documented in over 150 scientific publications and inventions - is included in permanent collections at MoMA, SFMOMA, Centre Pompidou, MFA, The Smithsonian Institution, and more. Her innovations have received recognition at the World Economic Forum where she is part of the Expert Network, and the White House. Since 2005, Oxman and her team have won numerous awards that have grown in international scope and acclaim. Among Oxman's awards are the Vilcek Prize in Design, the BSA Women in Design Award, the Silicon Valley Visionary Award, and Carnegie's Pride of America. In 2018 Oxman was honored with the National Design Award and the Design Innovation Medal. Most recently, Oxman was the recipient of the Honorary Fellowship by the Royal Institute of British Architects (2019) and the Contemporary Vision Award by San Francisco Museum of Modern Art (2019).

Job Titles:

• Co - Founder
• Executive Director

As the Co-Founder and Executive Director of the Pershing Square Sohn Research Alliance (PSSCRA), Dr. Olivia Tournay Flatto leads the establishment and implementation of the PSSCRA mission. Prior to joining the Alliance, Olivia spent a decade as President of the Emerald Foundation, an independently funded private medical research foundation based in New York City. She also served as Director of External Affairs at the New York Stem Cell Foundation (NYSCF). She started her research for her Ph.D. at the Wistar Institute in Philadelphia, PA in the laboratory of Dr. Frank Rauscher. Olivia completed her research in Dr. Robert Benezra's laboratory at the Sloan-Kettering Institute in New York City where she worked on the Id gene and its role in the molecular mechanism of mammalian cell differentiation. A native of France, Olivia received her Master's Degree from L'Université de Montpellier in Parasitology and Microbiology and her Ph.D. in Molecular Biology and Genetics from the University of Pennsylvania. She serves as President and on the Advisory Board of The Pershing Square Foundation. She is also on the boards of the Paris Opera and Ballet (chair) and the Institute of International Education, as well as a member of the Women's Forum of New York and the President's Circle of the National Academy of Sciences, Engineering, and Medicine.

Job Titles:

• CEO & Portfolio Manager, Pershing Square Capital Management, L.P
• CEO and Portfolio Manager of Pershing Square Capital
• Chairman of the Board of the Howard Hughes Corporation

William A. Ackman is the CEO and Portfolio Manager of Pershing Square Capital Management, L.P., an SEC registered investment adviser founded in 2003. Pershing Square is a concentrated research-intensive fundamental value investor in long and occasionally short investments in the public markets. Prior to forming Pershing Square, Mr. Ackman co-founded Gotham Partners Management Co., LLC, an investment adviser that managed public and private equity hedge fund portfolios. Prior to Gotham Partners, Mr. Ackman began his career in real estate investment banking at Ackman Brothers & Singer, Inc. Mr. Ackman received an MBA from the Harvard Business School and a Bachelor of Arts magna cum laude from Harvard College. Mr. Ackman is the Chairman of the board of The Howard Hughes Corporation (NYSE: HHC). He is a Trustee of The Pershing Square Foundation and a member of the Board of Dean's Advisors of the Harvard Business School.

Job Titles:

• Executive Chairman of Novocure Ltd.
• Executive Chairman, Novocure Ltd

Bill Doyle is the Executive Chairman of Novocure Ltd., a company commercializing a new therapeutic modality for solid tumors using low intensity electric fields. Recently, Novocure received FDA approval to treat recurrent Glioblastoma (GBM), the most common and deadly form of brain cancer. In 2002, Bill co-founded healthcare venture capital firm WFD Ventures. Prior to founding WFD, Bill served as an executive of Johnson & Johnson where he was a member of J&J's Medical Devices and Diagnostics Group Operating Committee with responsibility for licensing, acquisitions & strategy. Bill is a graduate of MIT and Harvard Business School. He serves as a member of the Dean's Advisory Board of Harvard Business School; Harvard Business School's Healthcare Advisory Board; and the MIT Corporation's Visiting Committee for Undergraduate Education.