BRIGHAM AND WOMEN'S HOSPITAL - Key Persons
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- Physician Assistant, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital
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- Recruitment Specialist, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital
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- Master of Biomedical Informatics )
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- Previous Fellow Co - Investigator
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- Professor of Anaesthesia
- Research
Prof. Charles Nicholas Serhan is the Simon Gelman Professor of Anaesthesia (Biochemistry and Molecular Pharmacology) at Harvard Medical School and Professor of Oral Medicine, Infection and Immunity at Harvard School of Dental Medicine. He is Director of the Center for Experimental Therapeutics and Reperfusion Injury at Brigham and Women's Hospital. In 1987, he joined the faculty at Harvard Medical School in 1987 and received an honorary degree from Harvard University (1996).
He has received several awards including an NIH MERIT award (2000) and has delivered > 50 keynote and plenary lectures. Among these, 2008 William Harvey Outstanding Scientist Medal and AAAS Fellow in 2011. In 2010, he received the Society for Leukocyte Biology Bonazinga Award for outstanding research on leukocytes, The American College of Rheumatology Hench (Nobel Laureate) Award Lecture in 2011 and is a Mérieux 2013 Laureate. In 2016, he received the IUBMB Lecture Metal and the Ross Prize in Molecular Medicine. In 2017, he received the International Eicosanoid Research Foundation's Lifetime Achievement Award and the American Society of Investigative Pathology (ASIP) 2018 Rous Whipple Award.
Dr. Serhan has over 25 years of experience leading multidisciplinary research teams and led as Principle Investigator/Program Director Program (PI/PD) Project "Molecular Mechanisms in Leukocyte-Mediated Tissue Injury" (P01-DE13499), PI/PD for "Specialized Center for Oral Inflammation and Resolution" (P50-DE016191) and currently is the PI/PD of "Resolution Mechanisms in Acute Inflammation: Resolution Pharmacology" (P01-GM095467) a program project grant supported by NIH/NIGMS. Importantly, he is hands-on at the bench and has trained > 60 fellows and trainees that has successful careers in academic medicine and industry.
Current research in the Serhan laboratory focuses on structural elucidation of novel bioactive molecules that activate the resolution of inflammation. Our overall mission is "To identify novel mediators, pathways, and their cellular receptors and targets critical in promoting resolution of inflammation and reperfusion tissue injury and establish their relation to human disease." Our ongoing studies focus on structural elucidation of novel molecules and pathways that are pro-resolving and endogenous anti-inflammatory chemical signals.
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- Previous Resident Co - Investigator
Cynthia Weiffenbach, RN, has been a nurse at BWH since 1981 and has been a cardiac nurse since 1992.
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- Resident Co - Investigator
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- Operations Manager, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital
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- Member of the Research Team
- Research Assistant
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- Co - Director, Center for Alzheimer Research and Treatment / Associate Professor of Neurology, HMS Departments of Neurology, BWH, MGH
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- Member of the Research Team
- Principal Investigator
- Clinical Regional Anesthesiologist
- Research
- Translational Pain Research
Dr. Kristin Schreiber is Neuroscientist and Clinical Regional Anesthesiologist investigating the development of chronic pain after surgical injury. She is particularly interested in the mechanisms by which individual differences in psychosocial processing and nociceptive sensitivity lead to differential risk of chronic pain amongst individuals. Her current research uses the accurate measurement of psychosocial and psychophysical phenotype in preoperative patients to prospectively identify individuals at highest risk of pain persistence, so that the processes underlying this propensity may be averted. Other collaborative projects investigate how pain may be modulated by non-opioid analgesic techniques (regional anesthesia, yoga-based exercise, distraction, music, CBT, and open-label placebo).
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- Division Chief
- Research Profile
Ellen M. Gravallese, MD, division chief and the Theodore Bevier Bayles Professor of Medicine at Harvard Medical School, is an internationally recognized and accomplished rheumatologist, immunologist and basic scientist. She completed her residency in internal medicine and pathology at the Brigham and served on the hospital's faculty from 1991 to 1998. After spending 13 years as chief of the Division of Rheumatology at UMass Medical School, she returned to the Brigham to lead our division in 2019.
Dr. Gravallese's research on fundamental mechanisms of inflammation and joint destruction in inflammatory arthritis has changed our understanding of the pathogenesis of rheumatoid arthritis and subsequent mechanisms of joint destruction in this disease. Among her many professional honors, she was the 2019-2020 president of the American College of Rheumatology and the 2019 recipient of the prestigious international Carol Nachman Prize for career achievements in rheumatology research.
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- Clinical Research Assistant, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital
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- Associate Medical Director of Clinical Trials, Center for Alzheimer Research and Treatment, BWH, MGH / Assistant Professor of Neurology, HMS
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- Clinical Research Assistant, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital
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- Previous Fellow Co - Investigator
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- Anesthesiologist at Brigham
- Research
Dr. Danny Muehlschlegel is an attending cardiovascular anesthesiologist at Brigham and Women's Hospital, where he is also the Vice Chair of Research, the Director of Cardiac Anesthesia Research, and an Associate Professor of Anesthesia at Harvard Medical School.
As a cardiac anesthesiologist with significant subspecialty training in all aspects of cardiac disease and transesophageal echocardiography, Dr. Muehlschlegel is a perioperative physician guiding the care of very sick patients with cardiovascular disease. His particular expertise is in the area of myocardial injury and its association with cardiac specific biomarker elevation, as well as in defining the role that the ECG has in the acute myocardial injury setting immediately post cardiac surgery.
In addition, Dr. Muehlschlegel is an NIH-funded physician-scientist with an active laboratory examining the impact of genetic variation upon adverse cardiovascular events and their significance on a functional level. He is the Principal Investigator of the TRANSCRIBE study (Transcriptomic Analysis of Left Ventricular Gene Expression), which aims to identify differential expression in human left ventricular myocardium upon exposure to ischemia, examine genetic variants that determine expression changes, and characterize these changes among different disease states.
Dr. Muehlschlegel is also the Chief Scientific Officer of Team Heart, a nonprofit medical organization focused on bringing sustainable cardiac care to Rwanda, a country with a very high incidence of rheumatic heart disease. In Rwanda, he initiated the genetics of rheumatic heart disease (RECHARGE) study, to investigate the genetic signal behind rheumatic heart disease and the molecular changes that accompany the valvular pathology.
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- Chairman, Department of Anesthesiology, Perioperative and Pain Medicine
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- Senior Administrative Assistant, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital
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- Professor of Anaesthesia, Harvard Medical School
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- Executive Director, Center for Advanced Heart Disease / Medical Director, Heart & Vascular Center
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- Clinical Trials Nurse Manager, Brigham and Women 's Hospital
Maryclare Hickey, RN, has worked as a nurse at BWH for almost 27 years, and has been a cardiac nurse for eight years.
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- Medical Director, Heart Transplant and Mechanical Circulatory Support Program
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- Member of the Research Team
- Post Doctoral Fellow
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- Co - Director of Outreach, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital / Massachusetts Alzheimer 's Disease Research Center
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- ProjectManager, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital
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- Clinical Research Assistant, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital
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- Director, Center for Alzheimer Research and Treatment / Professor of Neurology, HMS Memory Disorders Unit, BWH, MGH Departments of Neurology, BWH, MGH
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- Clinical Research Assistant, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital
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- Associate Neurologist, Brigham and Women 's Hospital Assistant Professor of Neurology, Harvard Medical School
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- Associate Neurologist, Brigham and Women 's Hospital, Instructor in Neurology, Harvard Medical School
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- Previous Fellow Co - Investigator
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- Clinical Research Assistant, Center for Alzheimer Research and Treatment, Brigham and Women 's Hospital